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Research

Dr. Jiang Chang

The lab is committed to the investigation of molecular and epigenetic mechanisms involved in cardiovascular diseases resulting from various clinical events such as myocardial infarction, hypertension, diabetes, obesity and others (PTSD). Dr. Chang also heads the Pre-Clinical Imaging Core.

Chang Lab
Pre-Clinical Imaging Core

Dr. Roderick Dashwood

Supported by ABC and R&R/Bioinformatics core facilities, current research encompasses histone and non-histone modifications, DNA methylation, and non-coding RNAs, in the continuum from computational modeling in silico, to cell-based assays and preclinical models, and human translational studies involving colorectal cancer patients.

Dashwood Lab
Antibody & Biopharmaceutics Core
Rigor & Reproducibility Core

Dr. Leng Han

In collaboration with high throughput research and screening center, and R&R/Bioinformatics core facilities, our lab utilizes the high-throughput technologies to dissect the molecular mechanism in complex diseases. We aim to identify novel therapeutic targets and to develop innovative therapeutic approaches.

Han Lab
High Throughput Research and Screening Center
Rigor & Reproducibility Core

Dr. Magnus Höök

The research in the Höök laboratory is focused on determining the molecular pathogenesis of infections and inflammatory diseases. We are interested in two key areas in the pathogenic process; microbial adherence to host tissue and microbial evasion of host defense systems. Ultimately, we seek to translate our research findings into new or improved strategies to prevent and treat infectious diseases. 

Höök Lab
Protein Production Core

Dr. Nancy Huang

Disruption of the fine balance between DNA methylation and demethylation can cause aberrant transcriptional outputs, increased genome instability, and 3D genome disorganization, which is frequently observed in human diseases. Dr. Huang ’s research interests are directed towards understanding how DNA methylation homeostasis is maintained in human and other mammals; how aberrant DNA methylation modifications contribute to developmental defects, metabolic disorders and oncogenesis. 

Huang Lab

Dr. Julian Hurdle

Dr. Hurdle’s research centers around three themes: (1) how Clostridium difficile evolves resistance to front-line antibiotics and the clinical impact of resistance on treatment outcomes; (2) discovering of novel therapeutic concepts for antibiotic-resistant infections; and (3) applying chemical genetic strategies to understand C. difficile pathogenic mechanisms. 

Hurdle Lab

Dr. Thomas Kent

Designing a new class of carbon nanotherapeutics to treat disorders of mitochondrial bioenergetics in neurological injury, aging and neurodegeneration. Focus on process of commercialization. Translational and clinical precision medicine stroke research.

Kent Lab

Dr. Jia Li

Applying computational methods to identify epigenetic biomarkers from cfDNA derived from cancer, and discover novel epigenetic mechanisms involved in cancer and development.

Li Lab

Dr. Weijia Luo

Exploring the early molecular signaling cross-talks between the heart and peripheral tissue in metabolic disease and stress-related disorders, aiming for early detection and prevention of cardiovascular diseases in these patients.

Luo Lab
Pre-Clinical Imaging Core

Dr. Margie Moczygemba

The research focus of the Moczygemba laboratory is to gain a deeper understanding of immune cell biology and apply this knowledge to the identification of novel therapeutics to treat inflammatory diseases. Specifically, we seek to develop interventional strategies that block allergic inflammation through our increased understanding of cytokine receptor signaling and eosinophil biology. We employ cutting-edge immunological, molecular and cellular, and biochemical techniques to identify novel targets capable of modulating inflammatory signals triggered by these immune cells.

Moczygemba Lab
Flow Cytometry Analysis and Cell Sorting

Dr. Praveen Rajendran

The Rajendran lab is identifying novel epigenetic approaches to the treatment and prevention of gastrointestinal cancers via exploiting faulty DNA repair mechanisms and genomic instability in cancer, leading to chemo-sensitization and enhanced cancer therapy.

Rajendran Lab
Antibody & Biopharmaceutics Core

Dr. Kenneth Ramos

The Ramos Laboratory focuses on the study of LINE-1 retroelements and their role in genome stability and disease. Current research builds on seminal discoveries by his group that defined genetic and epigenetic mechanisms of retrotransposon reactivation by DNA damaging agents.

Ramos Lab

Dr. David Reiner

A long-term goal of the Reiner lab is to understand the molecular basis underlying the contribution of signal transduction to development. What determines the extraordinarily high fidelity of developmental systems – and how novel signaling mechanisms and components contribute to that fidelity – remains a fundamental gap in the field. 

Reiner Lab

Dr. Cliff Stephan & the High Throughput Research Screening Center

The IBT High Throughput Research and Screening Center provides access to state-of-the-art tools to support the discovery of new drugs and new treatments for devastating diseases of our time.

Stephan Lab
High Throughput Research Screening Center

Dr. Robert Tsai

The development of Dr. Tsai’s research program follows two overarching directions of basic science and translational medicine. On the basic research front, his laboratory is focused on the molecular mechanism that drives the self-renewal of stem cells and cancer cells in the biological context of tissue regeneration, premature aging, as well as cancer development, prevention, and treatment. 

Tsai Lab

Dr. Fen Wang

The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. 

Wang Lab

Dr. Yi Xu

The Xu lab is interested in the general area of host-pathogen interactions. Recent focus is on elucidating the impact of gut microbes on intestinal homeostasis and function. We utilize the High Throughput Research and Screening Center, Pre-clinical Imaging Core and Protein Production Core to aid our research.

Xu Lab
High Throughput Research and Screening Center
Pre-Clinical Imaging Core
Protein Production Core

Dr. Dekai Zhang

Our laboratory studies the molecular mechanisms of Toll-like receptors in innate immune responses in infectious and inflammatory diseases, utilizing our Core facilities: Flow cytometry, advanced image core, and protein core.

Zhang Lab
Flow Cytometry Analysis and Cell Sorting
Advanced Imaging Core
Protein Production Core

Dr. Kurt Zhang

Zhang Lab is focused on development of bioinformatics and biostatistics methodology for studying the variations of biological systems, such as cell-cell cross talks and gene networks, during disease onset and progress. Our lab utilizes the services of the Rigor & Reproducibility Core at the IBT.

Zhang Lab
Rigor & Reproducibility Core

Dr. Yubin Zhou

The Zhou lab works at the interface of biology and chemistry by tightly integrating mechanistic studies with biomedical engineering and translational sciences, with a focus on calcium signaling, optogenetics, synthetic immunology, chemical biology, and epigenetics. The lab utilizes state-of-the-art advanced imaging, flow cytometry and cell sorting, pre-clinical imaging and high-throughput screening technologies housed at IBT.

Zhou Lab
Flow Cytometry Analysis and Cell Sorting
Pre-Clinical Imaging Core
High Throughput Research and Screening Center