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Y. Zhou Lab

Welcome to Zhou Lab

Our research is focused on elucidating the role of calcium channels in health and diseases. We are particularly interested in understanding how calcium ions are transported across membrane, how ion channels can be engineered to achieve tailored function, how calcium flux controls cell fitness and gene expression, and how dysregulated ion flux leads to human diseases (e.g., cancer, cardiovascular and immune diseases). To tackle these fundamental yet crucial problems, we use a broad range of approaches & techniques that include biochemistry, biophysics, protein design & engineering, chemical biology, nanotechnology, microscopy, optogenetics, bioinformatics and mouse genetics.