Recent Publications

Marreddy RKR, Phelps GA, Churion K, Picker J, Powell R, Cherian PT, Bowling JJ, Stephan CC, Lee RE, Hurdle JG. Chemical genetic analysis of enoxolone inhibition of C. difficile toxin production reveals adenine deaminase and ATP synthase as anti-virulence targets. J Biol Chem. 2024 Sep 27:107839. doi: 10.1016/j.jbc.2024.107839. Online ahead of print. PMID: 39343002

Liu A, Chokshi M, Nguyen N, Powell RT, Stephan CC, Bao G.|Cystic fibrosis cell models for high-throughput analysis and drug screening. J Cyst Fibros. 2024 Jul 25: S1569-1993(24)00788-4. doi: 10.1016/j.jcf.2024.07.001. Epub ahead of print. PMID: 39060183.

Junco JJ, Rochette M, Alozie M, Rashid R, Terrell M, Zorman B, Sumazin P, Rowland L, Dettorre G, Powell RT, Stephan CC, Davies PJ, Martinez-Moczygemba M, Yang JJ, Rabin KR. A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities. Haematologica. 2024 Jul 25. doi: 10.3324/haematol.2023.284761. Epub ahead of print. PMID: 39049603.

Powell RT, Rinkenbaugh AL, Guo L, Cai S, Shao J, Zhou X, Zhang X, Jeter-Jones S, Fu C, Qi Y, Baameur Hancock F, White JB, Stephan C, Davies PJ, Moulder S, Symmans WF, Chang JT, Piwnica-Worms H. Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer. NPJ Breast Cancer. 2024 May 27;10(1):37. doi: 10.1038/s41523-024-00644-4. PMID: 38802426

Joseph R, Dasari SK, Umamaheswaran S, Mangala LS, Bayraktar E, Rodriguez-Aguayo C, Wu Y, Nguyen N, Powell RT, Sobieski M, Liu Y, Kim MS, Corvigno S, Foster K, Hanjra P, Vu TC, Chowdhury MA, Amero P, Stephan C, Lopez-Berestein G, Westin SN, Sood AK. EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer. Int J Mol Sci. 2024 Jan 20;25(2):1278. doi: 10.3390/ijms25021278. PMID: 3827927

Bandy R, Shahi S, Quagraine N, Shahbazi Nia S, Howlader MSI, Srivenugopal K, Stephan C, Das H, Mikelis CM, German NA. Mechanistic Aspects of Biphenyl Urea-Based Analogues in Triple-Negative Breast Cancer Cell Lines. ACS Pharmacol Transl Sci. 2023 Dec 15;7(1):120-136. doi: 10.1021/acsptsci.3c00193. eCollection 2024 Jan 12. PMID: 38230276

Ghosh S, Fan F, Powell RT, Roszik J, Park Y, Stephan C, Sebastian M, Tan L, Sorokin AV, Lorenzi PL, Kopetz S, Ellis LM, Bhattacharya R. Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer. Mol Cancer Ther. 2023 Jun 13:MCT-23-0110. doi: 10.1158/1535-7163.MCT-23-0110. Epub ahead of print. PMID: 37310170.

Carter BZ, Mak PY, Muftuoglu M, Tao W, Baozhen K, Pei J, Bedoy AD, Ostermann LB, Nishida Y, Isqandarova S, Sobieski M, Nguyen N, Powell RT, Martinez-Moczyemba M, Stephan C, Basyal M, Pemmaraju N, Boettcher S, Ebert BL, Shpall EJ, Wallner BP, Morgan R, Karras GI, Moll U, Andreeff M. Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells. Blood. 2023 Jun 20:blood.2022019047. doi: 10.1182/blood.2022019047. Epub ahead of print. PMID: 37339579.

Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AHM, Asmussen JK, Katsonis P, Myers JN, Lai SY, Lu W, Stephan CC, Powell RT, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer. 2023 Jun;128(11):2013-2024. doi: 10.1038/s41416-023-02253-7. Epub 2023 Apr 3. PubMed PMID: 37012319; PubMed Central PMCID: PMC10205814.

Fan F, Ghosh S, Powell R, Roszik J, Park Y, Sobieski M, Sorokin A, Stephan C, Kopetz S, Ellis LM, Bhattacharya R. Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PLoS One. 2023;18(3):e0281063. doi: 10.1371/journal.pone.0281063. eCollection 2023. PubMed PMID: 36952536; PubMed Central PMCID: PMC10035898.

Dasari SK, Joseph R, Umamaheswaran S, Mangala LS, Bayraktar E, Rodriguez-Aguayo C, Wu Y, Nguyen N, Powell RT, Sobieski M, Liu Y, Chowdhury MA, Amero P, Stephan C, Lopez-Berestein G, Westin SN, Sood AK.Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer. Int J Mol Sci. 2023 Feb 15;24(4). doi: 10.3390/ijms24043915. PubMed PMID: 36835335; PubMed Central PMCID: PMC9962847.