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Recent Publications

Recent Publications

Paul A. Wadsworth, Aditya K. Singh, Nghi Nguyen, Nolan M. Dvorak, Cynthia M. Tapia, William K. Russella, Clifford Stephan, Fernanda Laezza. JAK2 regulates Nav1.6 channel function via FGF14Y158 phosphorylation. BBA. 2020 June 26;118786. doi: 10.1016/j.bbamcr.2020.118786. PubMed PMID: 32599005

Zhang H, Qi L, Du Y, Huang LF, Braun FK, Kogiso M, Zhao Y, Li C, Lindsay H, Zhao S, Injac SG, Baxter PA, Su JM, Stephan C, Keller C, Heck KA, Harmanci A, Harmanci AO, Yang J, Klisch TJ, Li XN, Patel AJ. Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma. Cancers (Basel). 2020 Jun 5;12(6). doi: 10.3390/cancers12061478. PubMed PMID: 32517016. 

Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SAW, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan CC, Mancini MA. Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity. Nucleic Acids Res. 2020 Feb 28;48(4):1800-1810. doi: 10.1093/nar/gkz1172. PubMed PMID: 31930333; PubMed Central PMCID: PMC7039002. 

Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep. 2020 Feb 21;10(1):3199. doi: 10.1038/s41598-020-60246-5. PubMed PMID: 32081928; PubMed Central PMCID: PMC7035246. 

Guo L, Li J, Zeng H, Guzman AG, Li T, Lee M, Zhou Y, Goodell MA, Stephan C, Davies PJA, Dawson MA, Sun D, Huang Y. A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nat Commun. 2020 Feb 6;11(1):740. doi: 10.1038/s41467-020-14604-6. PubMed PMID: 32029739; PubMed Central PMCID: PMC7005144.

Wadsworth PA, Folorunso O, Nguyen N, Singh AK, D'Amico D, Powell RT, Brunell D, Allen J, Stephan C, Laezza F. High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex. Sci Rep. 2019 Nov 15;9(1):16890. doi: 10.1038/s41598-019-53110-8. PubMed PMID: 31729429; PubMed Central PMCID: PMC6858373.

Li X1, Martinez-Ledesma E1,2, Zhang C1, Gao F1, Zheng S1, Ding J1, Wu S1, Nguyen N3, Clifford SC3, Wen PY4, Ligon KL4, Yung WKA1, Koul D5. Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma. Cancer Res. 2019 Oct 1;79(19):5088-5101. doi: 10.1158/0008-5472.CAN-19-0325. PMID: 31416846

Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA. GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res. 2019 Mar 7;21(1):37. doi: 10.1186/s13058-019-1125-0. PubMed PMID: 30845991.

Huang L, Brunell D, Stephan C, Mancuso J, He B, Thompson TC, Zinner R, Kim J, Davies P, Wong STC. Driver Network as a Biomarker: Systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction. Bioinformatics. 2019 Feb 15. pii: btz109. doi: 10.1093/bioinformatics/btz109. [Epub ahead of print] PubMed PMID: 30768150.

Chowdhury P, Powell RT, Stephan C, Uray IP, Talley T, Karki M, Tripathi DN, Park YS, Mancini MA, Davies P, Dere R. Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells. J Cell Sci. 2018 Dec 14;131(24). pii: jcs219923. doi: 10.1242/jcs.219923. PubMed PMID: 30518623; PubMed Central PMCID: PMC6307881.

Kalu NN, Mazumdar T, Peng S, Tong P, Shen L, Wang J, Banerjee U, Myers JN, Pickering CR, Brunell D, Stephan CC, Johnson FM. Comprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants. Cancer Lett. 2018 Sep 1;431:64-72. doi: 10.1016/j.canlet.2018.05.029. Epub 2018 May 25. PubMed PMID: 29807113.

McGrail DJ, Lin CC, Dai H, Mo W, Li Y, Stephan C, Davies P, Lu Z, Mills GB, Lee JS, Lin SY. Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype. Cell Rep. 2018 May 15;23(7):2095-2106. doi: 10.1016/j.celrep.2018.04.068. PubMed PMID: 29768207.

Dong J, Park SY, Nguyen N, Ezhilarasan R, Martinez-Ledesma E, Wu S, Henry V, Piao Y, Tiao N, Brunell D, Stephan C, Verhaak R, Sulman E, Balasubramaniyan V, de Groot JF. The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells. Oncotarget. 2018 Jan 8;9(12):10497-10509. doi: 10.18632/oncotarget.24041. eCollection 2018 Feb 13. PubMed PMID: 29535822; PubMed Central PMCID: PMC5828226.

Kogiso M, Qi L, Lindsay H, Huang Y, Zhao X, Liu Z, Braun FK, Du Y, Zhang H, Bae G, Zhao S, Injac SG, Sobieski M, Brunell D, Mehta V, Tran D, Murray J, Baxter PA, Yuan XJ, Su JM, Adesina A, Perlaky L, Chintagumpala M, Parsons DW, Lau CC, Stephan CC, Lu X, Li XN. Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma.Oncotarget. 2017 Sep 8;8(50):87455-87471. doi: 10.18632/oncotarget.20713. eCollection 2017 Oct 20. PubMed PMID: 29152094; PubMed Central PMCID: PMC5675646.

Kumar S, Peng X, Daley J, Yang L, Shen J, Nguyen N, Bae G, Niu H, Peng Y, Hsieh HJ, Wang L, Rao C, Stephan CC, Sung P, Ira G, Peng G. Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells. Oncogenesis. 2017 Apr 17;6(4):e319. doi: 10.1038/oncsis.2017.15. PubMed PMID: 28414320; PubMed Central PMCID: PMC5520492.

Szafran AT, Stephan C, Bolt M, Mancini MG, Marcelli M, Mancini MA. High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth. Prostate. 2017 Jan;77(1):82-93. doi: 10.1002/pros.23251. Epub 2016 Oct 4. PubMed PMID: 27699828; PubMed Central PMCID: PMC5956900.