Available Research Projects for Students and Postdocs

Jiang (JC) Chang, MD, PhD, FAPS Center for Genomic and Precision Medicine Department of Translational Medical Sciences

Texas A&M University College of Medicine Institute of Biosciences and Technology (IBT) 2121 W. Holcombe Blvd., Houston, TX 77030 jiangchang@tamu.edu

 #heartdisease #diabetes #nutrition #PTSD #biomarker

 

Our lab, located in TAMUHSC Alkek building, the heart of Houston, Texas Medical Center campus investigates the molecular and cellular mechanisms underlying prevalent cardiovascular diseases e.g., ischemic (myocardial infarction), hemodynamic (hypertension), metabolic (diabetes, obesity) or others (PTSD) challenges.

Our ultimate goal is to provide clinical translation for the prevention and treatment of pathological stressful cardiac remodeling and promote cardiac repair.

We have a consistent record of mentoring graduates, medical students and postdocs and prepare them to be competitive for prestigious awards/fellowships and successful careers. We invite graduate, medical students and postdocs to participate in the following projects:

 

1)     RhoE-mediated Sterile Inflammation Regulation in Acute Myocardial Infarction

The main purpose is to explore the regulatory role of RhoE in sterile inflammation in response to myocardial infarction. Supported by National Institute of Health (NIH).

2)     Epigenetic signaling and heart failure

This project investigates the epigenetic mechanism of heart failure and uncover potential therapeutic targets. Supported by NIH.

3)     Epigenetic signaling, pathological cardiac hypertrophy and Western diet

The main purpose is to uncover the initial epigenetic signaling mechanism in the heart in response to Western diet and the associated deleterious effects on the development of pathological cardiac remodeling. Supported by NIH.

4)     Exosomes in cardiovascular diseases

The goal is to generate genetic tool mouse that enables to track and quantify the endogenous exosomes released from the heart in live in vivo, and investigate their pathological significances in CV diseases. Supported by American Heart Association (AHA).

5)    Rho signaling in the development and treatment of myocardial infarction complication

The main purpose is to explore the mechanism of left ventricular aneurysm development during myocardial infarction and its relationship with Rho signaling. Supported by the AHA.

6)     Increased risk of heart disease after posttraumatic stress disorder in women: role of gonadal hormones and potential preventative interventions.

The main purpose is to uncover the risk factors among gonadal hormones contributing to the development of PTSD in women. Supported by Department of Defense (DOD).

7)     Brain, heart and systemic epigenetic and metabolic profile in posttraumatic stress disorder.

The goal is to define the epigenetic and metabolic profiles in brain, heart and blood following trauma exposure and emergence of PTSD-like symptomatology. Supported by TAMUHSC.