Jiang Chang, M.D., Ph.D., FAPS

Education and Training

• M.D. Wuhan University School of Medicine, Wuhan, China
• Ph.D., Texas A&M University, College Station, Texas
• Postdoc, Baylor College of Medicine, Houston, Texas

Research Interests

Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular and cellular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis as result of various pathological scenarios such as myocardial infarction, hypertension, obesity, diabetes, aging and post-traumatic stress disorder. The overall approach consists of generation and analysis of clinically-relevant genetic mouse models including a tool mouse enabling tracking endogenous cardiac exosomes, and conduct mechanistic studies using cutting-edge technology. The ultimate goal of our efforts is to provide clinical translation for the prevention and treatment of pathological cardiac remodeling from our mechanistic studies.

Selected Publications

1. Yuan Dai, Weijia Luo, Xiaojing Yue, Wencai Ma, Jing Wang and Jiang Chang. Identification and characterization of a new isoform of small GTPase RhoE. Commun Biol. 2020 Oct 15, 3(572). https://www.nature.com/articles/s42003-020-01295-4#citeas
2. Weijia Luo, Yuan Dai, Zhishi Chen, Xiaojing Yue, Kelsey C. Andrade-Powell and Jiang Chang. Spatial and temporal tracking of cardiac exosomes in mouse using a nano-luciferase-CD63 fusion protein. Commun Biol. 2020 Mar 10;3(1):114. PubMed PMID: 32157172.
3. Yuan Dai, Jiangping Song, Wenjiao Li, Tingli Yang, Xiaojing Yue, Xi Lin, Xiangsheng Yang, Weijia Luo, Junli Guo, Xin Wang, Songqing Lai, Kelsey C. Andrade, Jiang Chang. RhoE Fine-Tunes Inflammatory Response in Myocardial Infraction. Circulation. 2019 Feb 26; 139(9). PubMed PMID: 30586715; PubMed Central PMCID: PMC6532428.
4. Yuan Dai, Weijia Luo, Jiang Chang. Rho kinase signaling and cardiac physiology. Cur Opin in Physiol. 2018; 1:14-20. NIHMSID: NIHMS922648. PMID:29527586 PMCID: PMC5842951. (Inaugural issue).
5. Jin Cao, Yi Yu, Zhengmao Zhang, Xi Chen, Zhaoyong Hu, Qiang Tong, Jiang Chang, Xin-Hua Feng and Xia Lin. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes. Aug. 2017; db170546. PMID: 28851713 PMCID: PMC5741142 (Co-corresponding author).
6. Xin Yi, Ye Tao, Xi Lin, Yuan Dai, Tingli Yang, Xiaojing Yue, Xuejun Jiang, Yan Li, Ding-sheng Jiang, Kelsey C. Andrade, Jiang Chang. Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts. BBA-Mol Cell Res. 2017 Jan 24. pii: S0167-4889(17)30020-4. doi: 10.1016/j.bbamcr.2017.01.012. PMID:28130125.
7. Xiaojing Yue, Xi Lin, Tingli Yang, Xiangsheng Yang, Xin Yi, Xuejun Jiang, Xiaoyan Li, Junli Guo, Tianfa Li, Yuan Dai, Jianjian Shi, Lei Wei, Keith A. Youker, Guillermo Torre-Amione, Yanhong Yu, Kelsey C. Andrade, and Jiang Chang. Rnd3/RhoE Modulates HIF1α and regulates responsive cardiac angiogenesis. Hypertension. 2016 Jan 18. pii: HYPERTENSIONAHA.115.06412. [Epub ahead of print] PMID: 26781283 PMCID: PMC4752414.
8. Xiangsheng Yang, Tiannan Wang, Li, Xi Lin, Xiaojing Yue, Qiongling Wang, Guangliang Wang, Qin Fu, Xun Ai, David Y. Chiang, Christina Y. Miyake, Xander H.T. Wehrens and Jiang Chang. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Cir Res. 2015 Jan 2;116(1):e1-e10. doi: 10.1161/CIRCRESAHA.116.304940. Epub 2014 Oct 27. PubMed PMID: 25348166; PubMed Central PMCID: PMC4282622.
9. Xiaojing Yue, Xiangsheng Yang, Xi Lin, Tingli Yang, Xin Yi, Yuan Dai, Junli Guo, Tianfa Li, Jianjian Shi, Lei Wei, Guo-Chang Fan, Conan Chen and Jiang Chang. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell Death Dis. 2014 Jun 5;5:e1284. doi: 10.1038/cddis.2014.235. PubMed PMID: 24901055.
10. Xi Lin, Baohui Liu, Xiangsheng Yang, Xiaojing Yue and Jiang Chang. Rnd3 deficiency results in aqueductal stenosis contributing to hydrocephalus through upregulation of Notch signaling. Pro Nat Acad Sci USA, 2013 May 14;110 (20):8236-41. doi: 10.1073/pnas.1219995110. Epub 2013 Apr 29. PubMed PMID: 23630292 PubMed Central PMCID: PMC3657816.
11. Xiangsheng Yang, Qi Li, Xi Lin, Yanlin Ma, Xiaojing Yue, Zhenyin Tao, Fen Wang, Wallace L. Mckeehan, Lei Wei, Robert J. Schwartz and Jiang Chang. Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB J. Published online January 25 2012.  PubMed PMID: 22278938 PubMed Central PMCID: PMC3336781.
12. Xi Lin, Xiangsheng Yang, Qi Li, Yanlin Ma, Shuang Cui, Dacheng He, Xia Lin, Robert J. Schwartz and Jiang Chang. Protein tyrosine phosphatase‐like A regulates myoblast proliferation and differentiation through MyoG and cell cycling signaling pathway. Mol and Cell Bio. 32:297-308; 2012. PubMed PMID: 22106411 PubMed Central PMCID: PMC3255775.

Complete list of publications