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News and Publications


March 2021
We have joined Science Twitter! For quick updates on our latest publications and more, give us a follow here:

December 2020
After a trying year full of uncertainty and many changes in the lab, Dr. Chang has earned the Senior Investigator Research Excellence Award 2020 from TAMU's College of Medicine. Congratulations!

edges.jpg September 2020
Dr. Chang has received the Chancellor’s Research Initiative “EDGES” Award from Chancellor John Sharp in recognition of his significant research accomplishments. Congratulations Dr. Chang!
Texas A&M University Announces 2020 EDGES Fellows - Texas A&M Today

August 2020
Congratulations to our post-doc, Yuan Dai who won second place in the Academy for Research Excellence (ACRE) Young Investigator Award, 2020 with his virtual presentation titled, “Small GTPase RhoE Fine-tunes Inflammatory Response in Myocardial Infarction”!


November 2018
Texas A&M Health Science Center Vital Record
Improving Patient Outcomes After Heart Attack

February 2016
American Heart Association Awardees List - Tingli Yang

September 2014
American Heart Association Awardees List - Xiangsheng "Sean" Yang

July 2014
Pathways to Cardiovascular Therapeutics Program
 - Xiaojing Yue

April 23, 2013
"Institute of Biosciences and Technology researchers make connection between genetic defect and congenital hydrocephalus" 

Awards for Research Excellence by Trainees

  • Xiangsheng Yang
    • 3rd place, 15th Annual Student Research Symposium, TAMHSC, College Station, 2012
    • Travel Award, TAMHSC, College Station, 2012
    • AHA Postdoc Fellowship Award, 7/1/2013 – 6/30/2015
    • AHA-BCVS New Investigator Travel Award, Las Vegas, July 2014
    • AHA-ACRE Outstanding Presentation Awards, Chicago, November 2014
  • Yuan Dai
    • 2nd place, Academy for Research Excellence (ACRE) Young Investigator Award, 2020 
    • China Scholarship Council Scholarship Award, 9/12012 – 8/31/2016
    • Outstanding Young Investigator Award from ACRE, AHA Basic Cardiovascular Sciences 2016 scientific Sessions: Pathways to Cardiovascular Therapeutics. Phoenix, Arizona, July 18-21,
  • Xiaojing Yue
    • China Scholarship Council Scholarship Award, 9/12010 – 8/31/2014
    • AHA Cardiovascular Outreach Award, BCVS Conference, Las Vegas, July 2014
    • 1st place prize in AHA-BCVS, Academy of Cardiovascular Research Excellence (ACRE), Chicago, USA, July 2014
  • Tingli Yang
    • AHA Predoctoral Fellowship Award, 1/1/2016 – 12/31/2017.
  • Thao Ho
    • 1st Place, IBT Biotechnology Summer Research Program, August, 2019.
    • 1st Place, in undergraduate poster competition, American Physician Scientist Association Southern Regional Meeting, September 7 2019.
  • Weijia Luo
    • 1st Place, Young Investigator Award, the 1st Asian Cardiovascular Symposium, BCVS-AHA, Boston, Massachusetts, 7/29/2019 – 8/1/2019.
    • Department of Defense PRMRP Discovery Award 9/1/2020 – 8/31/2022

Thao Ho - 1st APSA Award

  • Summer undergraduate student Thao Ho won the 1st Place Program Award from the IBT Biotechnology Summer Research Program, 8/2019.
  • Ho also wont the 1st Place in undergraduate poster competition at the American Physician Scientist Association Southern Regional Meeting, 9/7/19.

Weijia Luo won 1st place of Young Investigator Award - AHA

  • Postdoc Weijia Luo, Ph.D., presented her exosome study at the 1st Asian Cardiovascular Symposium of the American Heart Association - Basic Cardiovascular Sciences in Bostin, MA 7/29/19-8/1/19.
  • Luo won 1st place in the Young Investigator Award category at the Asian Cardiovascular Symposium of the AHA, where young scientits from Asian countries joined to compete. 

Selected Publications

  1. Yuan Dai, Weijia Luo, Xiaojing Yue, Wencai Ma, Jing Wang and Jiang Chang. Identification and characterization of a new isoform of small GTPase RhoE. Commun Biol. 2020 Oct 15, 3(572).

  2. Weijia Luo, Yuan Dai, Zhishi Chen, Xiaojing Yue, Kelsey C. Andrade-Powell and Jiang Chang. Spatial and temporal tracking of cardiac exosomes in mouse using a nano-luciferase-CD63 fusion protein. Commun Biol. 2020 Mar 10;3(1):114. PubMed PMID: 32157172.

  3. Yuan Dai, Jiangping Song, Wenjiao Li, Tingli Yang, Xiaojing Yue, Xi Lin, Xiangsheng Yang, Weijia Luo, Junli Guo, Xin Wang, Songqing Lai, Kelsey C. Andrade, Jiang Chang. RhoE Fine-Tunes Inflammatory Response in Myocardial Infraction. Circulation. 2019 Feb 26; 139(9). PubMed PMID: 30586715; PubMed Central PMCID: PMC6532428.

  4. Yuan Dai, Weijia Luo, Jiang Chang. Rho kinase signaling and cardiac physiology. Cur Opin in Physiol. 2018; 1:14-20. NIHMSID: NIHMS922648. PMID:29527586 PMCID: PMC5842951. (Inaugural issue).

  5. Jin Cao, Yi Yu, Zhengmao Zhang, Xi Chen, Zhaoyong Hu, Qiang Tong, Jiang Chang, Xin-Hua Feng and Xia Lin. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes. Aug. 2017; db170546. PMID: 28851713 PMCID: PMC5741142 (Co-corresponding author).

  6. Xin Yi, Ye Tao, Xi Lin, Yuan Dai, Tingli Yang, Xiaojing Yue, Xuejun Jiang, Yan Li, Ding-sheng Jiang, Kelsey C. Andrade, Jiang Chang. Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts. BBA-Mol Cell Res. 2017 Jan 24. pii: S0167-4889(17)30020-4. doi: 10.1016/j.bbamcr.2017.01.012. PMID:28130125.

  7. Xiaojing Yue, Xi Lin, Tingli Yang, Xiangsheng Yang, Xin Yi, Xuejun Jiang, Xiaoyan Li, Junli Guo, Tianfa Li, Yuan Dai, Jianjian Shi, Lei Wei, Keith A. Youker, Guillermo Torre-Amione, Yanhong Yu, Kelsey C. Andrade, and Jiang Chang. Rnd3/RhoE Modulates HIF1α and regulates responsive cardiac angiogenesis. Hypertension. 2016 Jan 18. pii: HYPERTENSIONAHA.115.06412. [Epub ahead of print] PMID: 26781283 PMCID: PMC4752414.

  8. Xiangsheng Yang, Tiannan Wang, Li, Xi Lin, Xiaojing Yue, Qiongling Wang, Guangliang Wang, Qin Fu, Xun Ai, David Y. Chiang, Christina Y. Miyake, Xander H.T. Wehrens and Jiang Chang. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Cir Res. 2015 Jan 2;116(1):e1-e10. doi: 10.1161/CIRCRESAHA.116.304940. Epub 2014 Oct 27. PubMed PMID: 25348166; PubMed Central PMCID: PMC4282622.

  9. Xiaojing Yue, Xiangsheng Yang, Xi Lin, Tingli Yang, Xin Yi, Yuan Dai, Junli Guo, Tianfa Li, Jianjian Shi, Lei Wei, Guo-Chang Fan, Conan Chen and Jiang Chang. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell Death Dis. 2014 Jun 5;5:e1284. doi: 10.1038/cddis.2014.235. PubMed PMID: 24901055.

  10. Xi Lin, Baohui Liu, Xiangsheng Yang, Xiaojing Yue and Jiang Chang. Rnd3 deficiency results in aqueductal stenosis contributing to hydrocephalus through upregulation of Notch signaling. Pro Nat Acad Sci USA, 2013 May 14;110 (20):8236-41. doi: 10.1073/pnas.1219995110. Epub 2013 Apr 29. PubMed PMID: 23630292 PubMed Central PMCID: PMC3657816.

  11. Xiangsheng Yang, Qi Li, Xi Lin, Yanlin Ma, Xiaojing Yue, Zhenyin Tao, Fen Wang, Wallace L. Mckeehan, Lei Wei, Robert J. Schwartz and Jiang Chang. Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB J. Published online January 25 2012.  PubMed PMID: 22278938 PubMed Central PMCID: PMC3336781.

  12. Xi Lin, Xiangsheng Yang, Qi Li, Yanlin Ma, Shuang Cui, Dacheng He, Xia Lin, Robert J. Schwartz and Jiang Chang. Protein tyrosine phosphatase‐like A regulates myoblast proliferation and differentiation through MyoG and cell cycling signaling pathway. Mol and Cell Bio. 32:297-308; 2012. PubMed PMID: 22106411 PubMed Central PMCID: PMC3255775.

Complete List of Publications