Chetna Dureja
Postdoctoral Research Associate
Co-President, IBT Postdoctoral Association
Contact
Center for Infectious and Inflammatory Disease
2121 West Holcombe
Houston,
TX
77030
chetnadureja@exchange.tamu.edu
Hurdle Lab
Biography
Dr. Chetna Dureja is a passionate molecular microbiologist, dedicated to improving people's lives through research in infectious diseases. She is passionate about arts and crafts and finding beauty in creativity. She thrives on connecting with people and nurturing meaningful relationships with those around her. Her research on C. difficile is to understand mechanisms of antimicrobial resistance and their impact on patient care and to investigate the therapeutic potential of new anti-C. difficile agents. She is determined to develop innovative solutions to combat antimicrobial resistance to benefit individuals and society.
Representative Publications
- Abiola O. Olaitan*, Chetna Dureja*, Madison A. Youngblom, Madeline A. Topf, Wan-Jou Shen, Anne J. Gonzales-Luna, Aditi Deshpande, Kirk E. Hevener, Jane Freeman, Mark H. Wilcox, Kelli L. Palmer, Kevin W. Garey, Caitlin S. Pepperell, Julian G. Hurdle: Decoding a Cryptic Mechanism of metronidazole resistance among globally disseminated fluoroquinolone resistant Clostridioides difficile. Nature Communication, July 2023 (*Co-first author)
- Chetna Dureja, Jacob T. Rutherford, Krissida Norseeda, Sarah G. Whaley, Fahad BA Pavel, Dainqing Sun, Charles O Rock, Kirk E Hevener, Julian G Hurdle: The fatty acid biosynthesis isoenzyme FabK is a target for narrow-spectrum antibiotics for Clostridioides difficile infection. (Manuscript accepted for publication in AAC, Dec 2023)
- Anne J Gonzales-Luna, Chetna Dureja, Taryn A Eubank, Kevin W Garey, Julian G Hurdle: Surveillance of Clostridioides difficile antimicrobial resistance in the United States. Clinical Infectious Diseases, March 2023
- Chetna Dureja*, Abiola O Olaitan*, Julian G Hurdle: Mechanism and Impact of antimicrobial resistance in Clostridioides difficile. Current Opinion in Microbiology, Jan 2022 (*Co-first author)
- Krissada Norseeda, Fahad Bin Aziz Pavel, Jacob Rutherford, Humna N. Meer, Chetna Dureja, Julian G. Hurdle, Kirk E. Hevener, Dr. Dianqing Sun: Synthesis and evaluation of phenylimidazole FabK inhibitors as new anti-C. difficile agents. Bioorganic & Medicinal Chemistry, April 2023
- Chetna Dureja, Sakshi Mahajan, Saumya Raychaudhuri: Phylogenetic distribution and prevalence of genes encoding class I integrons and CTX-M15 extended-spectrum-β-lactamases in Escherichia coli isolates from healthy humans in Chandigarh, India. Plos One, Oct, 2014
- Indu Khatri, Sakshi Mahajan, Chetna Dureja, Srikrishna Subramanian, Saumya Raychaudhuri: Evidence of new metabolic capacity in an emerging diarrheal pathogen: lessons from the draft genomes of Vibrio fluvialis strains PG41 and I21563. Gut Pathogen, July, 2013
- Ranjana Tripathi*, Vikas Kaithwas*, Chetna Dureja*, Saumya Raychaudhuri: Alanine-scanning mutagenesis of WH2 domains of VopF reveals residues important for conferring lethality in a Saccharomyces cerevisiae model. Gene, May, 2013 (*Co-first author)
- Indu Khatri*, Chetna Dureja*, Saumya Raychaudhuri, Srikrishna Subramanian: Draft genome sequence of the opportunistic human pathogen Morganella morganii SC01. Genome Announcements, Jan, 2013 (*Co-first author)
- Mitesh Dongre, Naorem Santa Singh, Chetna Dureja, Nagesh paddada, Ashish K Solanki, Ashish, Saumya Raychaudhuri: Evidence on how a conserved glycine in the hinge region of hapR regulated its DNA binding ability. Journal of Biological Chemistry, April, 2011
- Mitesh Dongre, Neelam Khatri, Chetna Dureja, Saumya Raychaudhuri: Alanine-scanning mutagenesis of selected residues in the N-terminal region alters the functionality of LuxO: lessons from natural variants LuxOPL91. Journal of Medical Microbiology, Feb, 2011
- Ranjana Tripathi, Santa Singh Naorem, Chetna Dureja, Swati Haldar,Alok K. Mondal Saumya Raychaudhuri: VopF, a type III effector protein from a nonO1, non-O139 Vibrio cholerae strain, demonstrates toxicity in Sacchromyces cervisiae model. Journal of Medical Microbiology, Sep, 2009
- Suparna Ghosh, Chetna Dureja, Indu Khatri, Saumya Raychaudhuri, Sagarmoy Ghosh: Identification of novel small RNAs in Burkholderia cenocepacia KC-01 expressed under iron limitation and oxidative stress conditions. Microbiology, Nov, 2017
- Manpreet Kaur, Harjodh Singh, Manoj Jangra, Lakhwinder Kaur, Pallavi Jaswal, Chetna Dureja, Hemraj Nandanwar, Saumya Ray Chaudhuri, Manoj Raje, Sunita Mishra, Anil Kumar Pinnaka. Lactic acid bacteria isolated from yak milk show probiotic potential. Applied Microbiology and Biotechnology, Oct, 2017
- láudia Bessa, Joana Soares, Liliana Raimundo, Joana B. Loureiro1, Célia Gomes, Flávio Reis, Miguel Soares, Daniel Santos, Chetna Dureja, Saumya Ray Chaudhuri, Cynthia Lopez-Haber, Marcelo G. Kazanietz, Jorge Gonçalves, Maria F. Simões, Patrícia Rijo, Lucília Saraiva. Novel small molecule PKCα-selective activator: an encouraging anticancer agent in colon cancer therapy. Cell Death and Disease, Jan, 2018
- Taryn A. Eubank*, Chetna Dureja*, Kevin W. Garey, Julian G. Hurdle, Anne J. Gonzales-Luna: Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response. (Manuscript submitted) (*Co-first author)
- Jacob T. Rutherford, Kristiana Avad, Chetna Dureja, Krissada Norseeda, Bibek GC, Chenggang Wu, Dianqing Sun, Kirk E Hevener, Julian G. Hurdle: Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) As A Narrow-Spectrum Drug Target. (Manuscript submitted)