Yun Nancy Huang
, PhD
Associate Professor

Office: Room 404 / Lab: Room 429
Center for Epigenetics and Disease Prevention 
Institute of Biosciences & Technology
Texas A&M University Health Science Center
2121 W. Holcombe Blvd, Houston, TX 77030
Email:  yun.huang@tamu.edu
Phone: 713-677-7484 (office) 713-677-7485 (lab)
Faculty Bio

Education and Training

2003 Bachelor of Medicine (MD Equivalent), Zhejiang University, School of Medicine

2008 PhD, MS, Biochemistry, Georgia State University, Atlanta, GA

2009 Research Fellow, Immune Disease Institute, Harvard Medical School, Boston, MA
Program in Cellular and Molecular Medicine at Children's Hospital Boston

2010 Research Fellow, La Jolla Institute for Allergy and Immunology, La Jolla, CA

Research Interests

Disruption of the fine balance between DNA methylation and demethylation can cause aberrant transcriptional outputs, increased genome instability, and 3D genome disorganization, which is frequently observed in human diseases. Dr. Huang ’s research interests are directed towards understanding how DNA methylation homeostasis is maintained in human and other mammals; how aberrant DNA methylation modifications contribute to developmental defects, metabolic disorders and oncogenesis. My research goals are to:

(1) Define the dynamic changes of DNA methylation modifications (DNA methylome and hydroxymethylome) and their correlation with genome organization and gene transcription;

(2) Understand how additional regulators (including co-existing mutations, inflammation, microbiota, and metabolites) promote the malignant transformation of blood cells with epigenetic defects;

(3) Develop innovative single-cell epigenome analysis and epigenome-editing tools to probe how aberrant DNA modifications contribute to developmental defects and leukemogenesis.

Dr. Huang has significantly contributed to the characterization of the biological roles of Ten-eleven Translocation (TET) enzymes in heath and disease. Dr. Huang also pioneered the use of innovative methods to probe the “sixth DNA base”, 5-hydroxymethylcytosine (5hmC), in the human genome and was among the first to map the hydroxylmethylome in embryonic stem cells. Her studies resulted in over 90 peer-reviewed publications in top-notch scientific journals and over 7,300 citations (H index = 32). She was recruited to the Institute of Biosciences and Technology at Texas A&M University as a CPRIT scholar in 2014. She was featured as “Scientist to Watch” by the Scientist magazine. She also sits in the editorial board of the Blood journal. She was the recipient of multiple awards including the Leukemia & Lymphoma Society Fellow Award, the Rising Star Award from The American Medical Professional Foundation, The John S. Dunn Foundation Collaborative Research Award, The Cancer Fighter of Houston Foundation Award, and the Research Excellence Award from Texas A&M University. Her ongoing researches are supported by multiple grants from federal, state and private foundations.