Unho Jin, PhD

Biography

Education:

• PhD Degree (2002 – 2004):

  • Department of Life Science and Resources, DongA University Graduate School, Pusan, Korea.

• Master's Degree (2000 – 2002):

  • Department of Life Science and Resources, DongA University Graduate School, Pusan, Korea.

• Bachelor's Degree (1991 – 1997):

  • Department of Agricultural Chemistry, College of Natural Resources and Life Science, DongA University, Pusan, Korea.

Position and Employment:

• Current Position (2022 - Present):

  • Research Scientist, Texas A&M Health Science Center, Institute of Biosciences & Technology (IBT).

• Previous Positions:

  • Research Assistant Professor (2019 – 2022)

    • Department of Veterinary Physiology and Pharmacology (VTPP), Texas A&M University, College Station, Texas, USA.

  • Research Scientist (2014 – 2018)

    • Department of Veterinary Physiology and Pharmacology (VTPP), Texas A&M University, College Station, Texas, USA.

  • Associate Research Scientist (2010 – 2014)

    • Center for Environmental and Genetic Medicine (CEGM), Texas A&M Health Science Center, Houston, Texas, USA.

  • Post-Doc Researcher (2008 – Jul. 2010)

    • Center for Cardiovascular Genetics, Institute of Molecular Medicine (IMM), University of Texas, Houston, Texas, USA.

  • Research Assistant Professor (2004 – 2008)

    • Sungkyunkwan University, Korea.

Research Focus:

Dr. Unho Jin is a highly accomplished research scientist with a rich academic background and extensive professional experience. His research has primarily centered around the study of the novel anti-metastatic and anti-oncogenic roles of the Aryl Hydrocarbon Receptor (AHR) in various human cancers, including brain, colon, pancreatic, blood, and breast cancer.

The Aryl Hydrocarbon Receptor (AHR), a ligand-activated nuclear transcription factor, has been a focal point of Dr. Jin's investigations. His work has involved exploring the binding of AHR to structurally diverse endogenous compounds, industrial products, pharmaceuticals, microbiota-derived metabolites, and health-promoting phytochemicals.

Utilizing an array of biochemical, molecular biological, and proteomic tools, Dr. Jin has delved into the mechanisms underlying the therapeutic actions of AHR and its activators in human cancer. His contributions include the identification of synthetic compounds that activate AHR and inhibit metastasis in various cancer types.

In his most recent work, Dr. Jin has made significant strides in understanding the anti-oncogenic function of AHR in brain cancer invasion. Using patient-derived glioblastoma cell lines (PDX) and CRISPR/Cas9-KO cell lines, he has provided valuable insights into the role of AHR in brain cancer. Additionally, Dr. Jin is actively involved in screening AHR agonists to develop novel small-molecule targeted therapies, as demonstrated by his publications in esteemed journals such as Cancers (2020 PMID: 32731514) and the Journal of Biological Chemistry (2019 PMID: 31171720).

Dr. Unho Jin's dedication to advancing our understanding of AHR and its implications in cancer research underscores his commitment to making meaningful contributions to the field of biosciences and technology.