The Clinicogenomics programs at Texas A&M University are meticulously crafted to investigate complex systems issues that significantly influence healthcare outcomes within populations affected by chronic diseases. These comprehensive programs delve into a myriad of factors, encompassing genetic, psychosocial, socioeconomic, environmental, occupational, operational/delivery, and access/coverage aspects, aiming to provide a holistic understanding of the intricate interplay between various determinants and their impact on patient well-being.