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Research News

News on our work, A Nucleolar Mechanism Controlling Cell Proliferation in Stem Cells and Cancer Cells”, published in 2002 Genes Dev. Vol 16. No 23. p2991-3003

  • Bernardi, R. and Pandolfi, P.P. (2003) The Nucleolus: At the Stem of Immortality. Nat Med. Vol. 9 No. 1 p24-25
  • Heinrichs, A. (2003) Endless Cycling. Nat Rev Mol Cell Bio. Vol. 4. p7
  • Kirschweger, G. and Frederickson, R.M. (2003) Nucleostemin-A New Therapeutic Target and Tool? Mol Ther. Vol. 7. No. 1. p3-4

News on our work, A Multistep, GTP-driven Mechanism Controlling the Dynamic Cycling of Nucleostemin”, published in 2005 J Cell Biol. Vol. 168. No. 1. p179-184

  • Misteli, T. (2005) Going in GTP cycles in the Nucleolus. J Cell Biol. 168. No. 1. p177-178
  • This Week in ST: Trapped in the Nucleolus by GTP. Sci. STKE. Vol. 2005. p37
  • Swaminathan, S. (2005) Nucleolar Targeting Runs on GTP Cycles. Nat Cell Biol. Vol. 7. No. 3. p217

News on our work, GTP Depletion Synergizes the Anti-Proliferative Activity of Chemotherapeutic Agents in a Cell Type-Dependent Manner”, published in 2011 Biochem Bioph Res Co. Vol. 414. No. 2. p403-408.

  • McNichols, J. (2013) Stem Cell Protein Yields Hope for Cancer Patients. TAMHSC News
  • Awarded US Patent No. 9,492,426

News on our work, Nucleostemin Prevents Telomere Damage by Promoting PML-IV Recruitment to SUMOylated TRF1”, published in 2012 J Cell Biol. Vol. 197. No. 5. p613-624

  • J Cell Biol. Biobytes (2012) Telomere Protection by Nucleostemin
  • David, R. (2012) Telomeres: A New Level of Protection. Nat Rev Mol Cell Bio. Vol. 13. No. 7. p408

News on our work, Nucleostemin Deletion Reveals An Essential Mechanism That Maintains The Genomic Stability of Stem and Progenitor cells”, published in 2013 Proc Natl Acad Sci USA. Vol. 110. No. 28. p11415-11420

  • Burgess, D.J. (2013) Stem Cells: Maintaining Genomic Integrity. Nat Rev Genetics. Vol. 14. p520
  • Neural Cell News25 June 26 (2013)
  • Williamson, B. (2013) Researchers Reveal Guardian of The Stem Cell Genome. TAMHSC News
  • Pointer, E. (2013) KRHD-TV ABC40 news report
  • Houston Medical Times (2013) Houston Researchers Reveal Guardian of the Stem Cell Genome

News on our work, A Novel Role of Nucleostemin in Maintaining the Genome Integrity of Dividing Hepatocytes during Mouse Liver Development and Regeneration”, published in 2013 Hepatology Vol. 58. No. 6. p2176-2187

  • Lambert, H. (2013) Texas A&M Researchers Discover Mechanism to Prevent DNA Damage during Liver Regeneration. TAMHSC News
  • Ishibashi, A. (2013) Texas A&M Researchers Reveal Nucleostemin Protein Prevents DNA Errors In Cell Replication. BioNews Texas

News on our work, “Designing A Novel Mucoadhesive ChemoPatch to Ablate Oral Dysplasia for Cancer Prevention”, published in 2022 Small Vol. 18 (21). 202201561

  • Awarded as the 2022 cohort of the TMCi Accelerator for Cancer Therapeutics Program for Commercialization
  • US PCT Application “Biodegradable Mucoadhesive Pharmaceutical Formulations and Methods Thereof”
  • CADRx Inc. (https://leukoplax.com/)