September 3, 2015  

A mini review entitled "SOCE and cancer: recent progress and new perspectives" was accepted by International Journal of Cancer.

August 31, 2015 

Congratulations to Ji Jing  & Lian He for the acceptance of a research article by Nature Cell Biology, entitled "Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx" (doi: 10.1038/ncb3234).

July 22, 2015 

An online protocol describing "proteomic mapping of ER-PM junctions in living HEK293 cells" byLian He et al. was available at Protocol Exchange.

July 17th, 2015

An article entitled "Inside-out Ca2+ signalling prompted by STIM1 conformational switch" by Zhou Y et al. was published online (doi:10.1038/ncomms8826) by Nature Communications. 2015,6:Article 7826.

July 14th, 2013

An article entitled "Initial activation of STIM1, the regulator of store-operated calcium entry" by Zhou Y et al. was published online (doi:10.1038/nsmb.2625) by Nature Structural & Molecular Biology. 2013,20:973-981.

Highlighted in NSMB "NEWS AND VIEWS"
conformational dynamics of STIM1 activation

June 3rd, 2013

A book chapter entitled " STIM-ORAI interactions that control the CRAC channel" by Gudlur A, Zhou Y and Hogan PG was published online by Current Topics in Membranes[PMID: 23890110]

May 10, 2013

Congratulations to Lian He, M.S., for winning the poster award at the 2013 Annual IBT Research Symposium!


[32]  Jing J*, He L*, Sun A*, Quintana A*, Ding Y*, Ma G, Tan P, Liang X, Zheng X, Chen L, Zhang SL, Shi X, Zhong, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a novel regulator of Ca2+ influx. Nature Cell Biology. 2015 (Accepted)

[31]  Ma G*, Wei M*, He L*, Liu C*, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wag J, Wang Y, and Zhou Y. Inside-out Ca2+ signaling prompted by STIM1 conformational switch. Nature Communications. 2015,6:7826 (PMID: 26184105)

[30]  Bai H, Chen W, Wu W, Ma Z, Zhang H, Jiang T, Zhang T, Zhou Y, Du L, Shen Y and Li M. Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors. RSC Advance. 2015,6:7826 (in press)

[29]  Liu Z, Wang B, Ma Z, Zhou Y, Du L and Li M. Fluorogenic probe for the human Ether-a-Go-Go-related gene potassium channel imaging. Analytical Chemistry. 2015,87(5):2550-4. (PMID: 25665091)

[28]  Gudlur A*, Quintana A*, Zhou Y, Hirve N, Mahapatra S, Hogan PG. STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel. Nature Communications. 2014,5:5164 (PMID: 25296861)

[27]  Zhou MH, Zheng H, Si H, Jin Y, Peng MJ, He L, Zhou Y, Munoz-Garay C, Zawieja DC, Kuo L, Xu P, Zhang SL. Stromal interaction molecule 1 (STIM1) and Orai mediate histamine-evoked calcium entry and NFAT signaling in human umbilical vein endothelial cells. The Journal of Biological Chemistry. 2014, 289(42):29446-56. (PMID: 25190815)

[26]  Zhou Y, Srinivasan P, Razavi S, Seymour S, Meraner P, Gudlur A, Stathopulos PB, Ikura M Rao A and Hogan PG. Initial activation of STIM1, the regulator of store-operated calcium entry. Nature Structural & Molecular Biology2013,20:973-981. [PMID: 23851458]  

     Highlighted in NSMB "News and Views": “conformational dynamics of STIM1 activation

[25] Gudlur A, Zhou Y, and Hogan PG.  STIM-ORAI interactions that control the CRAC channel.Current Topics in Membranes. 2013,71:33-58. [PMID:23890110]

[24] Zhou Y, Xue S, Frey TK and Yang JJ. Probing Ca2+ binding capability of viral proteins with the EF-hand motif by grafting approach. Methods in Molecular Biology. 2013,963:37-53. (PMID: 23296603)

[23] Zhou Y, Xue S, and Yang JJ. Calciomics: integrative studies on Ca2+ binding proteins and their interactomes in biological systems. Metallomics. 2013,5(1):29-42. (PMID: 23235533)

[22] Zhou Y, Rao A and Hogan PG. “ORAI store-operated calcium channel” for the second Edition of the “Encyclopedia of Biological Chemistry", Elsevier. 2013:359-366.

[21] Zhou Y, Xue S, Chen Y, and Yang JJ. “Calcium and viruses” for “Encyclopedia of Metalloproteins”, Springer. 2013.

[20] Zhou Y*, Meraner P*, Kwon, HT, Machnes D, Oh-hora Masatsugu, Zimmer Jochen, Huang Y, Stura A, Rao A and Hogan PG. STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nature Structural & Molecular Biology. 2010,17(1):112-116. (PMID: 20037597)

[19] Zhou Y, Ramachandran S, Oh-hora M, Rao A and Hogan PG. Pore architecture of the ORAI1 store-operated calcium channel. Proceedings of the National Academy of Sciences USA. 2010,107(11):4896-901. (PMID: 20194792)

[18] Chen Y, Zhou Y, Lin X, Wong HC, Xu Q, Jiang J, Wang S, Lurtz MM, Louis CF, Veenstra RD, Yang JJ. Molecular interaction and functional regulation of connexin50 gap junctions by calmodulin. Biochemical Journal. 2011. 435(3):711-22. (PMID: 21320072)

[17] Zhou Y, Tzeng WP, Wong HC, Ye Y, Jiang J, Chen Y, Huang Y, Suppiah S, Frey TK, and Yang JJ. Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.The Journal of Biological Chemistry. 2010,285(12):8855-68. (PMID:20086014)

[16] Huang Y*,  Zhou Y*, Wong HC, Castiblanco A, Chen Y, Brown EM, Yang JJ. Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression. The Journal of Biological Chemistry. 2010,285(46):35919-31. (PMID: 20826781; *: Equal contribution)

[15] Chen Y, Xue S, Zhou Y and Yang JJ. Calciomics: prediction and analysis of EF-hand calcium binding proteins by protein engineering. Science China Chemistry. 2010,53(1):52-60. (PMID: 20802784)

[14] Jiang J, Zhou Y, Zou J, Chen Y, Patel P, Yang JJ, Balog EM. Site-specific modification of calmodulin Ca²(+) affinity tunes the skeletal muscle ryanodine receptor activation profile. Biochemical Journal. 2010,432(1):89-99. (PMID: 20815817)

[13] Jiang Y, Huang Y, Wong HC,  Zhou Y, Wang X, Yang J, Hall RA, Brown EM and Yang JJ.Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation. The Journal of Biological Chemistry. 2010,285: 33463-74. (PMID: 20705606)

[12] Huang Y,  Zhou Y, Wong, HC, Chen Y, Chen Y, Wang S, Castiblanco A, Liu A and Yang JJ. A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+. FEBS Journal. 2009,276(19):5589-97. (PMID: 19694801)

[11] Zhou Y, Frey TK, Yang JJ. Viral calciomics: interplays between Ca2+ and virus. Cell Calcium. 2009,46(1):1-17. (PMID: 19535138)

[10] Zhou Y, Yang W, Lurtz M, Chen Y, Jiang J, Huang Y, Louis CF, and Yang JJ. CCalmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions. Biophysical Journal. 2009, 96(7):2832-48. (PMID:19348766)

[9] Zhou Y, Tzeng WP, Ye Y, Huang Y, Chen Y, Frey TK, Yang JJ. A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication. Biochemical Journal. 2009, 417(2):477-83. (PMID: 18795894)

[8] Huang Y, Zhou Y, Castiblanco A, Yang W, Brown EM, Yang JJ. Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response. Biochemistry. 2009, 48(2):388-98. (PMID: 19102677) [highlighted on the journal’s home page]

[7] Yang JJ, Yang J, Wei L, Zurkiya O, Yang W, Li S, Zou J, Zhou Y, Maniccia AL, Mao H, Zhao F, Malchow R, Zhao S, Johnson J, Hu X, Krogstad E, Liu ZR. Rational design of protein-based MRI contrast agents.  Journal of the American Chemical Society. 2008, 130(29):9260-7. (PMID: 18576649)

[6] Zhou Y, Tzeng WP, Yang W, Zhou Y, Ye Y, Lee HW, Frey TK, Yang J. Identification of a Ca2+-binding domain in the rubella virus nonstructural protease.  Journal of Virology. 2007, 81(14):7517-28. (PMID: 17475644)

[5] Zhou Y, Yang W, Lurtz MM, Ye Y, Huang Y, Lee HW, Chen Y, Louis CF, Yang JJ. Identification of the calmodulin binding domain of connexin 43. The Journal of Biological Chemistry. 2007,282(48):35005-17. (PMID: 17901047)

[4] Huang Y*, Zhou Y*, Yang W, Butters R, Lee HW, Li S, Castiblanco A, Brown EM, Yang JJ. Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor. The Journal of Biological Chemistry. 2007, 282(26):19000-10. (PMID: 17478419; *: Equal contribution)

[3] Liu Y,  Zhou Y, Lee HW, Yang JJ, Bühring HJ, Chen YT, Ha B, Chen CX, Yang Y, Zen K., Lee HW, Yang JJ. Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47. Journal of Molecular Biology. 2007;19;365(3):680-93. (PMID: 17070842)

[2] Zhou Y, Yang W, Kirberger M, Lee HW, Ayalasomayajula G, Yang JJ. Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins. Proteins: Structure, Function and Bioinformatics. 2006;65(3):643-55. (PMID: 16981205)

[1] Zhou Y, Zhou W, Zhang Y. Research advances of two-dimensional electrophoresis based proteomic application in biological fluids. Chinese Journal of Pharmacology and Toxicology. 2003,17(4):292-97.


Hogan P, Zhou Y, Rao A, Meraner P, Machnes D. Assay for ORAI calcium channel regulations. U.S. Prov. App. No. 61/218,783. International application No: PCT/US2010/039340

Yang JJ, Liu Z, Li S, Zhou Y, Jiang J, Xue S, Qiao J, Wei L. Contrast Agents and Methods for Preparing Contrast Agents. International application No: PCT/US2009/39276.