Selected Publications Prior to 2013

Tsai, R.YL. and McKay, R.DG.* (2000) Cell Contact Regulates Fate Choice by Cortical Stem Cells. J Neurosci. Vol. 20. No. 10. p3725-3735

Tsai, R.YL. and McKay, R.DG* (2002) A Nucleolar Mechanism Controlling Cell Proliferation in Stem Cells and Cancer Cells. Genes Dev. Vol 16. No 23. p2991-3003

Bernardi, R. and Pandolfi, P.P. (2003) The Nucleolus: At the Stem of Immortality. Nat
Med. Vol. 9 No. 1 p24-25

Heinrichs, A. (2003) Endless Cycling.  Nat Rev Mol Cell Bio. Vol. 4. p7

Kirschweger, G. and Frederickson, R.M. (2003) Nucleostemin-A New Therapeutic Target and Tool? Mol Ther. Vol. 7. No. 1. p3-4

Tsai, R. YL.* and McKay, R.DG (2005) A Multistep, GTP-driven Mechanism Controlling the Dynamic Cycling of Nucleostemin. J Cell Biol. Vol. 168. No. 1. p179-184

Misteli, T. (2005) Going in GTP cycles in the Nucleolus. J Cell Biol. Vol. 168. No. 1. p177-178

This Week in ST: Trapped in the Nucleolus by GTP. Sci. STKE. Vol. 2005. p37

Swaminathan, S. (2005) Nucleolar Targeting Runs on GTP Cycles. Nat Cell Biol. Vol. 7. No. 3. p217

Zhu, Q., Yasumoto, H., and Tsai, R. YL.* (2006) Nucleostemin Delays Cellular Senescence and Negatively Regulates TRF1 Protein Stability. Mol Cell Biol. Vol. 24. No. 26. p9279-9290

Zhu, Q., Meng, L., Hsu, J.K., Lin, T., Teishima, J., and Tsai, R.YL.* (2009) GNL3L Stabilizes the TRF1 Complex and Promotes Mitotic Transition. J Cell Biol. Vol. 185. No. 5. p827-839

Lin, T., Meng, L., Li, Y., and Tsai, R.YL.* (2010) Tumor-Initiating Function of Nucleostemin-Enriched Mammary Tumor Cells. Cancer Res. Vol. 70. No. 22. p9444-9452

Hsu, J.K., Lin, T., and Tsai, R.YL.* (2012) Nucleostemin Prevents Telomere Damage by Promoting PML-IV Recruitment to SUMOylated TRF1. J Cell Biol. Vol. 197. No. 5. p613-624

J Cell Biol. Biobytes (2012) Telomere Protection by Nucleostemin

David, R. (2012) Telomeres: A New Level of Protection. Nat Rev Mol Cell Bio. Vol. 13. No. 7. p408


Selected Publications from 2013

Meng, L., Lin, T., Peng, G., Hsu, J., Lee S., Lin, SY., and Tsai, R.YL.* (2013) Nucleostemin Deletion Reveals An Essential Mechanism That Maintains The Genomic Stability of Stem and Progenitor cells. Proc Natl Acad Sci USA. Vol. 110. No. 28. p11415-11420

Burgess, D.J. (2013) Stem Cells: Maintaining Genomic Integrity. Nat Rev Genetics. Vol. 14. p520

Neural Cell News 7.25 June 26 (2013)

Williamson, B. (2013) Researchers Reveal Guardian of The Stem Cell Genome. TAMHSC News

Pointer, E. (2013) KRHD-TV ABC40 news report

Houston Medical Times (2013) Houston Researchers Reveal Guardian of the Stem Cell Genome

Lin, T., Ibrahim, W., Peng, C-Y., Finegold, M.J., and Tsai, R.YL.* (2013) A Novel Role of Nucleostemin in Maintaining the Genome Integrity of Dividing Hepatocytes during Mouse Liver Development and Regeneration. Hepatology. Vol. 58. No. 6. p2176-2187

Lambert, H. (2013) Texas A&M Researchers Discover Mechanism to Prevent DNA Damage during Liver Regeneration. TAMHSC News

Ishibashi, A. (2013) Texas A&M Researchers Reveal Nucleostemin Protein Prevents DNA Errors In Cell Replication. BioNews Texas

Lin, T., Meng, L., Lin, T-C., Wu, L.J., Pederson, T., Tsai, R.YL.* (2014) Nucleostemin and GNL3L Exercise Distinct Functions in Genome Protection and Ribosome Synthesis, Respectively. J Cell Sci. Vol. 127. No. 10. p2302-2312.

Huang, G., Meng, L., and Tsai, R.YL.* (2015) p53 Configures The G2/M Response of Nucleostemin-Deficient Cells. Cell Death Discov. Vol. 1. e15060

Tsai, R.YL.* (2018) Creating A Graft Friendly Environment for Stem Cells in Diseased Brains. J Clin Invest. Vol. 128. No. 1. p116-9

Lin, T., Lin, T-C., McGrail, D.J., Bhupal, P.K., Ku, Y-H., Zhang, W., Meng, L., Lin, S-Y., Peng, G., Tsai, R.YL.* (2019) Nucleostemin Reveals A Dichotomous Nature of Genome Maintenance in Mammary Tumor Development. Oncogene. Vol. 38. No. 20. p3919-31

Wang, J., McGrail, D.J., Bhupal, P.K., Zhang, W., Lin, K-Y, Ku, Y-H., Lin, T., Wu, H., Tsai, K.C., Li, K., Peng, C-Y, Finegold, M.J., Lin, S-Y., Tsai, R.YL.* (2020) Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress. Mol Cancer Res. Vol. 18. No. 5. p723-34