Five Most Significant Publications Prior to 2013

Liu, M., Chen, T.-Y., Ahamed, B., Li, J. and Yau, K.-Y.  1994.  Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel.   Science   266, 1348-1354. (Research Article)

Liu, M., and Simon, M.I.  1996.  Regulation by cAMP-dependent protein kinase of a G-protein mediated phospholipase C.   Nature   382, 82-87 (1996).

Stafford, L.J., Xia, C., Ma, W., Cai, Y., and Liu, M. (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein coupled receptor. Cancer Res.62: 5399-5404.

Hsu, Y-C., Chern, J.J., Cai, Y., Liu, M., and Choi, K.W. (2007) Drosophila homolog of TCTP regulates cell growth and proliferation through regulation of dRheb GTPase. Nature 445 (7129), 785-788.

Weng, J., Cheng, X., Luo, J., Jin, C., Zhou, X., Qu, J., Tong, L., Ai, D., Li, D., Wang, J., Amendt, B., Martin, J.F., and Liu, M. 2008. Deletion of G-protein coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down regulation of Pitx2. Proc. Natl. Acad. Sci. 105, 6081-6086.

Publications 2013

Fang Y, Chen Y, Yu L, Zheng C, Qi Y, Li Z, Yang Z, Zhang Y, Shi T, Luo J, Liu M.  2013.  Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1. J Natl Cancer Inst. 2013 Jan 2;105(1):47-58. doi: 10.1093/jnci/djs485. Epub 2012 Nov 24. PMID: 23178439

Wu H, Chen L, Zhang X, Zhou Q, Li JM, Berger S, Borok Z, Zhou B, Xiao Z, Yin H, Liu M, Wang Y, Jin J, Blackburn MR, Xia Y, Zhang W.  2013.  Aqp5 is a new transcriptional target of dot1a and a regulator of aqp2.  PLoS One 2013;8(1):e53342. Epub 2013 Jan 10.  PMID: 23326416

Liu S, Qian Y, Li L, Wei G, Guan Y, Pan H, Guan X, Zhang L, Lu X, Zhao Y, Liu M, Li D. 2013. Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. J Biol Chem. 2013 Mar 29;288(13):8794-803; discussion 8804. doi: 10.1074/jbc.M112.436204. Epub 2013 Feb 7. PMID: 23393138 (Paper of the Week)

Wang R, Wang Y, Liu N, Ren C, Jiang C, Zhang K, Yu S, Chen Y, Tang H, Deng Q, Fu C, Wang Y, Li R, Liu M, Pan W, Wang P. 2013. FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Res. 2013 Jun;23(6):803-19. doi: 10.1038/cr.2013.42. Epub 2013 Mar 19. PMID: 23507969

Qian Y, Liu S, Guan Y, Pan H, Guan X, Qiu Z, Li L, Gao N, Zhao Y, Li X, Lu Y, Liu M, Li D. 2013. Lgr4-mediated Wnt/β-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development. 2013 Apr;140(8):1751-61. doi: 10.1242/dev.093641. PMID: 23533175

Du B, Luo W, Li R, Tan B, Han H, Lu X, Li D, Qian M, Zhang D, Zhao Y, Liu M. 2013. Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression.  J Biol Chem. 2013 May 24;288(21):15131-41. doi: 10.1074/jbc.M113.455535. Epub 2013 Apr 15. PMID: 23589304

Qiu Z, Liu M, Chen Z, Shao Y, Pan H, Wei G, Yu C, Zhang L, Li X, Wang P, Fan HY, Du B, Liu B, Liu M, Li D. 2013. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases.  Nucleic Acids Res. 2013 Jun;41(11):e120. doi: 10.1093/nar/gkt258. Epub 2013 Apr 28. PMID: 23630316

Wang Y, Dong J, Li D, Lai L, Siwko S, Li Y, Liu M. 2013. Lgr4 Regulates Mammary Gland Development and Stem Cell Activity through the Pluripotency Transcription Factor Sox2. Stem Cells. 2013 May 27. doi: 10.1002/stem.1438. [Epub ahead of print] PMID: 23712846.

Siwko S, Lai L, Weng J, Liu M. 2013. Lgr4 in ocular development and glaucoma. J Ophthalmol. 2013;2013:987494. doi: 10.1155/2013/987494. Epub 2013 Jun 5. PMID: 23840940

Luo W, Rodriguez M, Valdez JM, Zhu X, Tan K, Li D, Siwko S, Xin L, Liu M. 2013. Lgr4 is a key regulator of prostate development and prostate stem cell differentiation. Stem Cells. 2013 Jul 29. doi: 10.1002/stem.1484. [Epub ahead of print] PMID: 23897697

Wang J, Liu R, Wang F, Hong J, Li X, Chen M, Ke Y, Zhang X, Ma Q, Wang R, Shi J, Cui B, Gu W, Zhang Y, Zhang Z, Wang W, Xia X, Liu M, Ning G. 2013.  Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol. 2013;15(12):1455-63. doi: 10.1038/ncb2867. doi: 10.1038/ncb2867. PMID: 24212090

Li D, Qiu Z, Shao Y, Chen Y, Guan Y, Liu M, Li Y, Gao N, Wang L, Lu X, Zhao Y, Liu M. 2013.  Heritable gene targeting in the mouse and rat using a CRISPR-Cas system.  Nat Biotechnol. 2013 Aug 8;31(8):681-3. doi: 10.1038/nbt.2661. PMID: 23929336

Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z, Zhao C, Siwko S, Shi T, Wang P, Xiao J, Liu M, Luo J. 2013.  GPR116, an Adhesion G-Protein Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway.  Cancer Res.  2013 Oct 15; 73(20):6206-18. doi: 10.1158/0008-5472. CAN-13-1049. Epub 2013 Sep 5.  PMID: 24008316

Publications 2014

Yi T, Weng J, Siwko S, Luo J, Li D, Liu M. 2014. Lgr4/Gpr48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. J Biol Chem PMID: 24519938.

Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, Liao L, Luo H, Fu J, Liu M, Yi Z, Xiao J, Li X. 2014. PKA turnover by the REGg-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2014.02.007 PMID: 24560667.

Wang F, Zhang X, Wang J, Chen M, Fan N, Ma Q, Liu R, Wang R, Li X, Liu M, Ning G. 2014. LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver. J Mol Endocrinol 2014 Feb 24: 52(2): 133-43. Doi: 10.1530/JME-13-0042 PMID: 24353284.

Dang Y, Liu B, Xu P, Zhu P, Zhai Y, Liu M, Ye X. 2014. Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating wnt signal pathway. PLoS One 2014. Mar 3;9(3):e89835. Doi: 10.137/journal.pone.0089835. PMID: 24595031.

Pan H, Cui H, Liu S, Qian Y, Wu H, Li L, Guan Y, Guan X, Zhang L, Fan HY, Ma Y, Li R, Liu M, Li D. 2014. Lgr4 gene regulates Corpus Luteum Maturation through Modulation of the WNT mediated EGFR-ERK Signaling Pathway. Endocrinology. 2014 Sep; 155(9):3624-37. PMID: 24877628

Guan X, Duan Y, Zeng Q, Pan H, Qian Y, Li D, Cao X, Liu M.  2014.  Lgr4 Deficiency Induces Ataxia-like Phenotype in Mice and Impairs Long-term Depression at Cerebellar Parallel fiber-Purkinje Cell Synapses.  J Biol Chem. 2014 Sep 19; 289(38):26492-504. PMID: 25063812

Cui H, Wang Y, Huang H, Yu W, Bai M, Zhang L, Bryan BA, Wang Y, Luo J, Li D, Ma Y, Liu M. 2014. GPR126 Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Signaling. J Biol Chem. 2014 Dec 12;289(50):34871-85.  PMID: 25217645.

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. 2014. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333:43-64. PMID: 25424900

Shao Y, Guan Y, Wang L, Qiu Z, Liu M, Chen Y, Wu L, Li Y, Ma X, Liu M, Li D. 2014.  CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos. Nature Protoc. 2014 Oct; 9(10):2493-512.  PubMed PMID: 25255092.

Guan Y, Shao Y, Li D, Liu M. 2014. Generation of site-specific mutations in the rat genome via CRISPR/Cas9. Methods Enzymol. 2014; 546:297-317. PMID: 25398346

Li P, Liu Y, Wang H, He Y, Wang X, He Y, Lv F, Chen H, Pang X, Liu M, Shi T, Yi Z. 2014. PubAngioGen: a database and knowledge for angiogenesis and related diseases. Nucleic Acids Res. 2015 Jan; 43 (Database issue):D963-7.  PMID: 25392416

Yang F, Zhang T, Wu H, Yang Y, Liu N, Chen A, Li Q, Li J, Qin L, Jiang B, Wang X, Pang X, Yi Z, Liu M, Chen Y. 2014. Design and optimization of novel hydroxamate-based histone deacetylase inhibitors of Bis-substituted aromatic amides bearing potent activities against tumor growth and metastasis. J Med Chem. 2014 Nov 26; 57(22):9357-69. PMID: 25360834

Zheng C, Fang Y, Tong W, Li G, Wu H, Zhou W, Lin Q, Yang F, Yang Z, Wang P, Peng Y, Pang X, Yi Z, Luo J, Liu M, Chen Y.  2014. Synthesis and Biological Evaluation of Novel Tetrahydro-β-carboline Derivatives as Antitumor Growth and Metastasis Agents through Inhibiting the Transforming Growth Factor-β Signaling Pathway.  J Med Chem. 2014 Feb 13;57(3):600-12. [Epub ahead of print].  PMID: 24417479.

Wu J, Yu L, Yang F, Li J, Wang P, Zhou W, Qin L, Li Y, Luo J, Yi Z, Liu M, Chen Y. 2014. Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents.  Eur J Med Chem. 2014 Jun 10; 80C:340-351. PMID: 24794770

Wang B, Yu W, Guo J, Jiang X, Lu W, Liu M, Pang X. 2014. The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in non-small cell lung cancer. J Pharmacol Exp Ther. 2015 Jan; 352(1):129-38. PMID: 25352499

Wang J, Zhang L, Chen G, Zhang J, Li Z, Lu W, Liu M, Pang X. 2014. Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway.  Breast Cancer Res Treat.  2014 Nov; 148(2):279-89. PMID: 25301089

Du B, Liu M. 2014. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Sci China Life Sci. 2014 Jun; 57(6):645-6. PMID: 24801571

Li R, Tan B, Yan Y, Ma X, Zhang N, Zhang Z, Liu M, Qian M, Du B. 2014. Extracellular UDP and P2Y6 Function as a Danger Signal to Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-β Production. J Immunol. 2014 Nov 1; 193(9):4515-26. PMID: 25261483.

Dong Y, Zhang T, Li J, Deng H, Song Y, Zhai D, Peng Y, Lu X, Liu M, Zhao Y, Yi Z. 2014. Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling. PLoS One. 2014 Dec 8; 9(12):e113830. PMID: 25485753

Ren H, Teng Y, Tan B, Zhang X, Jiang W, Liu M, Jiang W, Du B, Qian M. 2014. TLR triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infect Immun. 2014 Dec; 82(12):5076-85. PMID: 25245808.

Zhang T, Chen Y, Li J, Yang F, Wu H, Dai F, Hu M, Lu X, Peng Y, Liu M, Zhao Y, Yi Z. 2014. Antitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer. Neoplasia. 2014 Aug; 16(8):665-77. PMID: 25220594

Dang Y, Liu B, Xu P, Zhu P, Zhai Y, Liu M, Ye X. 2014. Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway.  PLoS One. 2014 Mar 3; 9(3):e89835. PMID: 24595031.

Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, Liao L, Luo H, Fu J, Liu M, Yi Z, Xiao J, Li X. 2014. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis.  J Mol Cell Cardiol. 2014 Jul; 72:28-38. PMID: 24560667

Wang F, Zhang X, Wang J, Chen M, Fan N, Ma QY, Liu RX, Wang R, Li X, Liu M, Ning G. 2014. LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver. J Mol Endocrinol. 2014 Feb 24; 52(2):133-43. doi: 10.1530/JME-13-0042. PMID: 24353284

Rodriguez M, Luo W, Weng J, Zeng L, Yi Z, Siwko S, Liu M. 2014. PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-κB. Oncogenesis. 2014 Aug 11; 3:e114. doi: 10.1038/oncsis.2014.29. PMID: 25111863.

Tan KCho SGLuo WYi TWu XSiwko SLiu MYuan W. 2014. KiSS1-Induced GPR54 Signaling Inhibits Breast Cancer Cell Migration and Epithelial-Mesenchymal Transition via Protein Kinase D1.  Curr Mol Med. 2014; 14(5):652-62. PMID: 24894166

Wang Y, Cho SG, Wu X, Siwko S, Liu M. 2014. G-protein coupled receptor 124 (GPR124) in endothelial cells regulates vascular endothelial growth factor (VEGF)-induced tumor angiogenesis. Curr Mol Med. 2014 May; 14(4):543-54. PMID: 24730523.

Publications 2015

Xu JG, Huang C, Yang Z, Jin M, Fu P, Zhang N, Luo J, Li D, Liu M, Zhou Y, Zhu Y. 2015. Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs). J Biol Chem. 2015 Jan 23; 290(4):2455-65. PMID: 25480784

Hu M, Peng S, He Y, Qin M, Cong X, Xing Y, Liu M, Yi Z. 2015. Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.  Oncotarget. 2015 Apr 12. [Epub ahead of print], PMID: 25915156

Dai F, Chen Y, Huang L, Wang J, Zhang T, Li J, Tong W, Liu M, Yi Z. 2015. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway.  J Cell Mol Med. 2015 Feb; 19(2):383-95. PMID: 25351103

Li J, Zhang T, Yang F, He Y, Dai F, Gao D, Chen Y, Liu M, Yi Z. 2015. Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, through down-regulating EGFR expression. Br J Pharmacol. 2015 Apr 17. doi: 10.1111/bph.13165. [Epub ahead of print] PMID: 25884486

Song D, Meng T, Xu W, Hou T, Lin Z, Yin H, Li B, Zhou L, Wang T, Han S, Fan T, Miao W, Liu M, Luo J, Zhou W, Li Z, Xiao J. 2015. 5-Fluoruracil blocked giant cell tumor progression by suppressing osteoclastogenesis through NF-kappaB signals and blocking angiogenesis. Bone. 2015 May 5. pii: S8756-3282(15)00168-4.  PMID: 25956534

Zhu J, Hou Q, Dong XD, Wang Z, Chen X, Zheng D, Zhou L, He C, Liu M, Tu L, Qu J. 2015. Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation. PLoS One. 2015 Mar 26; 10(3):e0119599. doi: 10.1371/journal.pone.0119599. eCollection 2015. PMID: 25811370

Zhou W, Huang A, Zhang Y, Lin Q, Guo W, You Z, Yi Z, Liu M, Chen Y. 2015. Design and optimization of hybrid of 2, 4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents. Eur J Med Chem. 2015 Apr 13; 96:269-280. doi: 10.1016/j.ejmech.2015.04.027. [Epub ahead of print] PMID: 25899332

Deng L, Jiang C, Chen L, Jin J, Wei J, Zhao L, Chen M, Pan W, Xu Y, Chu H, Wang X, Ge X, Li D, Liao L, Liu M, Li L, Wang P. 2015. The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation. Mol Cell. 2015 Apr 29. pii: S1097-2765(15)00254-3. PMID: 25936802

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