Recent Publications

Five Most Significant Publications Prior to 2012

Liu, L., A. Vo, G. Liu, and W.L. McKeehan (2005) Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction (MAGD). Cancer Res. 65: 4191-4201.

Liu, L, Xie, R, Yang, C and McKeehan, WL (2009) Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death. Cell. Oncol. 31: 393-405.

Xie, R, Nguyen, S., McKeehan, WL and Liu, L. (2010) Acetylated microtubules are required for fusion of autophagosomes with lysosomes.  BMC Cell Biol. 11: 89 [Epub 2010 Nov 22].

Xie, R, Nguyen, S, McKeehan, K, Wang, F, McKeehan, WL and Liu, L (2011) Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.  J. Biol. Chem. 286:10367-77 [EPub 2011 Jan 24].

Xie R, Wang F, McKeehan WL, Liu L. (2011) Autophagy enhanced by microtubule and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.  Cancer Res. 71:7537-46 [Epub 2011 Oct 28]

Publications 2012

Zhang J, Liu J, Huang Y, Chang JYF, Liu L, McKeehan WL, Martin JF, and Wang F (2012) FRS2a-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circulation Research 110(4):e29-39. [Epub 2011 Dec 29] PMID: 22207710

Liu L, McKeehan WL, Wang F, Xie R. (2012) MAP1S enhances autophagy to suppress hepatocarcinogenesis. Autophagy 8(2): 278-280. [EPub 2012 Feb 1] PMID: 22301994.

Zhang J, Liu J, Liu L, McKeehan WL, Wang F. (2012) The fibroblast growth factor signaling axis controls cardiac stem cells differentiation through autophagy regulation. Autophagy 8(4): 690-691.  PMID: 22302007. PMCID: PMC3405844

Klionsky DJ, …… Liu L, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4): 445-544. PMID: 22966490. PMCID: PMC3404883

Publications 2013

Zhao S, Ma W, Zhang M, Tang D, Shi Q, Xu S, Zhang X, Liu Y, Song Y, Liu L, Zhang Q. (2013) High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients. Medical Oncology 2013, 30(1): 335. PMID: 23263825. DOI 10.1007/s12032-012-0335-4.

Zou J, Yue F, Jiang X, Li W, Yi J, Liu L.  (2013) Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.  Biochem J. 2013 454(3): 447-457 [Epub 2013 Jul 3]  PMID: 23822101.

Publications 2014

Zou J, Yue F, Li W, Song K, Jiang X, Yi J and Liu L*. Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin. PLOS ONE 2014, 9(4): e94903. PMID: 24722279.  PMCID: PMC3983268. doi: 10.1371/journal.pone.0094903.

Jiang X, Li X, Huang H, Jiang F, Lin Z, He H, Chen Y, Yue F, Zou J, He Y, You P, Wang W, Yang W, Xu G, Li T, Zhao H, Lai Y, Wu Y, Yang M, Wang F, Zhong W and Liu L*.  Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis of human patients with prostate cancer.  Cancer 2014, 120 (8): 1228-1236.  PMID: 24390809. PMCID: PMC3981875. First published online 3 JAN 2014, DOI: 10.1002/cncr.28551.

Publications 2015

Jiang X, Zhong W, Huang H, He H, Jiang F, Chen Y, Yue F, Zou J, Li X, He Y, You P, Yang W, Lai Y, Wang F, Liu L*. Autophagy Defects Suggested by Low Levels of Autophagy Activator MAP1S and High Levels of Autophagy Inhibitor LRPPRC Predict Poor Prognosis of Prostate Cancer Patients. Molecular Carcinogenesis 2015, 54(10): 1194-1204. PMID: 25043940. First published online 2014 Jul 7. doi: 10.1002/mc.22193. [Epub ahead of print].

Zou J, Li W, Misra A, Yue F, Song K, Chen Q, Guo G, Yi J, Kimato J, Liu L*. Viral Restriction Factor Tetherin Prevents Leucine-rich Pentatricopeptide Repeat Containing Protein (LRPPRC) from Association with Beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and Enhances Autophagy and Mitophagy. Journal of Biology Chemistry 2015 Mar 13. 290 (11): 7269-7279. PMID: 25631043. PMCID: PMC4358145. doi:10.1074/jbc.M114.627679. [Epub ahead of print]

Chen Q, Yue F, Li W, Zou J, Xu T, Huang C, Zhang Y, Song K, Xu G, Huang H, Li J, Liu L* Potassium Bisperoxo (1,10-phenanthroline) Oxovanadate (bpV(phen)) Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. Journal of Biology Chemistry 2015 October 23 290 (43): 26051-26058. PMID: 26363065. Sep 11.pii: jbc.M115.653568 [Epub ahead of print].

Yue F, Li W, Zou J, Chen Q, Xu G, Xu Z, Zhang S, Gallinari P, Wang F, McKeehan WL, Liu L* Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin. Aging 2015 Sep 28, 7(10): 839-53.

Li Q, Lai Y, Wang C, Xu G, He Z, Shang X, Sun Y, Zhang F, Liu L*, Huang H*. Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through the NF‑κB signaling pathway. Oncology Reports 2016 Jan 35:375-381. 2015 October 7, DOI: 10.3892/or.2015.4341.

Song K, Hu W, Yue F, Zou J, Li W, Chen Q, Yao Q, Sun W, Liu L* Transforming Growth Factor TGFβ Enhances Microtubule-associated Protein MAP1S and Autophagy in Pancreatic Ductal Adenocarcinomas. PLoS One 2015 Nov. 16, DOI: 10.1371/journal.pone.0143150.

Shi M, Zhang Y, Liu L, Zhang T, Han F, Cleveland J, Wang F, McKeehan WL, Li Y, Zhang D. MAP1S controls bacterial phagocytosis through TLR signaling. Journal of Biology Chemistry M115.687376.  First published on November 12, 2015, doi:10.1074/jbc.M115687376

Li W, Zou J, Yue F, Song K, Chen Q, McKeehan WL, Wang F, Xu G, Huang H, Yi J, and Liu L* Defects in MAP1S-mediated autophagy cause reduction of mouse lifespans especially when fibronectin is overexpressed. Aging Cell In press.

Xu G, Jiang Y, Liu X, Yue F, Xiao Y, Jiang X, Li W, Huang H, Li X, He Y, Chen Q, Jonasch E, Liu L*. The MAP1S-activated autophagy degradation of lipid droplets impedes the development of clear cell renal cell carcinomas and improves patient prognosis. Oncotarget In press.

For a complete list of publications, please visit: