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News and Publications


December 22, 2020

Researchers at Texas A&M say caffeine could help play a role in fighting off some viruses like COVID-19. See interview with Dr. Yubin Zhou and Dr. Nancy Huang here:

September 3, 2015  

A mini review entitled "SOCE and cancer: recent progress and new perspectives" was accepted by International Journal of Cancer.

August 31, 2015 

Congratulations to Ji Jing  & Lian He for the acceptance of a research article by Nature Cell Biology, entitled "Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx" (doi: 10.1038/ncb3234).

July 22, 2015 

An online protocol describing "proteomic mapping of ER-PM junctions in living HEK293 cells" byLian He et al. was available at Protocol Exchange.

July 17th, 2015

An article entitled "Inside-out Ca2+ signalling prompted by STIM1 conformational switch" by Zhou Y et al. was published online (doi:10.1038/ncomms8826) by Nature Communications. 2015,6:Article 7826.

July 14th, 2013

An article entitled "Initial activation of STIM1, the regulator of store-operated calcium entry" by Zhou Y et al. was published online (doi:10.1038/nsmb.2625) by Nature Structural & Molecular Biology. 2013,20:973-981.

Highlighted in NSMB "NEWS AND VIEWS" conformational dynamics of STIM1 activation.

June 3rd, 2013

A book chapter entitled " STIM-ORAI interactions that control the CRAC channel" by Gudlur A, Zhou Y and Hogan PG was published online by Current Topics in Membranes[PMID: 23890110]

May 10, 2013

Congratulations to Lian He, M.S., for winning the poster award at the 2013 Annual IBT Research Symposium!


Highlighted Work

"Optogenetics Sparks Research Tools", NIH Biomedical Beat, April 2018

News coverage available here.

Recent Publications

Selected Publications (from 120+ research articles; 3800+ citation; H-index; 35)

He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Siwko S, Huang Y, Wang Y, and Zhou Y. Engineering of a bona fide light-operated calcium channel. Nature Communications. 2020 (accepted)

Wang T, He L, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y. Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style. Advanced Science. (IF: 16) 2020,2002148. (accepted) *Featured as a Cover article.

Ma G, He L, Liu S, Xie J, Huang Z, Jing J, Lee, YT, Wang R, Luo H, Han W, Huang Y and Zhou Y. Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nature Communications. 2020,11(1):1039. (PMID: 32098964) *Highlighted in Commentary by Cell Calcium: “Natural photoswitches exposes STIM1 activation steps

Yang X, Ma G, Zheng S, Qin X, Li X, Du L, Wang Y, Zhou Y#, and Li M#. Optical control of CRAC channel using photoswitchable azopyrazoles. Journal of the American Chemical Society. 2020,142(20):9460-9470. (PMID: 32330031) *Featured by JACS as a Cover article.

Li, J, Zhao S, Lee M, Yin Y, Li J, Zhou Y, Ballester LY, Esquenazi Y, Dashwood RH, Davies PJA, Parsons DW, Li XN, Huang Y, and Sun D. Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma Science Advances. 2020,6(42):eabb5427. (PMID: 33067228) *Highlighted in “Vital Record”.

Zhang Z, Jing J, Ye Y, Chen Z, Jing Y, Li S, Hong W, Ruan H, Liu Y, Hu Q, Huang Y, Li W, Lin C, Diao L, Zhou Y#, and Han L#. Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors. Genome Medicine. 2020 (accepted)

Guo L, Li J, Zeng H, Guzman A, Li T, Lee M, Zhou Y, Stefan C, Goodell MA, Stephan C, Davies PJA, Dawson M, Sun D, and Huang Y.A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi resistant leukemia cells. Nature Communications. 2020,11(1):740. (PMID: 32029739)

Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, Li T, Hill MC, Mo W, Xu R, Wang F, Chang J, Zhou Y, Sun D, Martin JF, and Huang Y. Tet inactivation disrupts YY1 binding and long-range chromatin interactions to cause developmental defects in embryonic heart. Nature Communications. 2019,10(1):4297. (PMID: 31541101)

Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang HY, and Wang RF. Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development. The Journal of Clinical Investigation. 2019,129(12):5261-77. (PMID: 31503548).

Tang J, Robichaux M, Wu KL, Pei J, Nguyen NT, Zhou Y, Wensel TG, and Xiao H. Single-atom fluorescence switch: a general approach towards visible light-activated dyes for biological imaging. Journal of the American Chemical Society. 2019,141(37):14699-706. (PMID: 31450884)

Liu Z, Li H, He L, Yu X, Tian C, Tan P, Li C, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, and Zhou Y. Discovery of small molecule inhibitors of the HSP90-Calcineurin-NFAT pathway against glioblastoma. Cell Chemical Biology. 2019,26(3):352-65. (PMID: 30639261) *Highlighted as Cover Story; Featured in Vital Record and The Battalion.

Li A, Cho JH, Reid B, Tseng CC, He L, Tan P, Yeh CY, Wu P, Li Y, Widelitz R, Zhou Y, Zhao M, Chow R, Chuong CM. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nature Communications. 2018, 9(1):5377. (PMID: 30560870)

Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, and Zhou Y. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLOS Biology. 2018,16(11):e3000051. (PMID: 30408026) *Highlighted as Editor’s Picks in cancer cell signaling; Featured in “Vital Record”.

Zheng S, Ma G, He L, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko RM, Gill DL, Dong H, Zhou Y#, and Wang Y#. Identification of molecular determinants that govern distinct STIM2 activation dynamics. PLOS Biology. 2018,16(11):e2006898. (PMID: 30444880; #: senior authors)

Sang L, Hu H, Liu G, Tian T, Ma G, Lu Y, Liu Z, Pan R, Li R, Piao H, Marks JR, Yang L, Yan Q, Wang W, Shao J, Zhou Y, Zhou T, and Liu A. LncRNA CamK-A regulates Ca2+-signaling-mediated tumor microenvironment remodeling. Molecular Cell. 2018,71(1):71-83. (PMID: 30220516)

Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao WM, Dashwood R, Han L, Dong WG, Zhou Y#, Wei-Guo Dong#, and Huang Y#. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene2018 (PMID: 30390073; #: senior authors)

Gudlur A, Zeraik AE, Hirve N, Rajanikanth V, Bobkov AA, Ma G, Zheng S, Wang Y, Zhou Y, Komvies EA, Hogan PG. Calcium sensing by the STIM1 ER-luminal domain. Nature Communications. 2018,9(1):4536. (PMID: 30382093)

Ma G, Zhang Q, He L, Nguyen NT, Liu S, Gong Z, Huang Y and Zhou Y. Genetically encoded tags for real time dissection of protein assembly in living cells. Chemical Science. 2018, 9(25):5551-9. (PMID:30061986). *Highlighted in theme collection of 2018 Chemical Science Hot Articles and Chem Sci Pick of the week by Royal Society of Chemistry. Feature by Clinical Lab ProductsFront Line Genomics, and Futurity.

Ma G, Liu J, Ke Y, Liu X, Li M, Wang F, Han G, Huang Y, Wang Y and Zhou Y. Optogenetic control of voltage gated calcium channels. Angewandte Chemie. 2018 (PMID: 29569306). *Highlighted as Cover story; Feature by BioOptics World and Photonics Media.

Nguyen NT, He L, Martinze-Moczygemba M, Huang Y and Zhou Y. Rewiring calcium signaling for precise transcriptional reprogramming. ACS Synthetic Biology. 2018,7(3):814-21. (PMID: 29489336). *Feature by The BattalionPhotonics MediaBioOptics World and Futurity.

Lee M, Li J, Liang Y, Ma G, Zhang J, He L, Liu Y, Li M, Sun D, Zhou Y# and Huang Y#. Engineered split-TET2 enzyme for inducible epigenetic remodeling. Journal of the American Chemical Society. 2017,139(13):4659-62. (PMID: 28294608; # lead contact) *Highlighted in ACS Editor’s Choice; Featured in JACS Spotlights and Vital Records.

Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W and Goodell MA. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nature Communications. 2017,8:16026 (PMID: 28695892).

Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Yao J, Ke L, Wang S, Park P, Marks J, Zhou Y, Zhou J, Heung MC, Liang H, Hu Z, Shen H, Hawke DH, Han LZhou Y, Lin C, and Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nature Cell Biology. 2017, 19(3):238-51. (PMID: 28218907) *Highlighted in Nat Rev Mol Cel Bio.

He L, Jing J, Zhu L, Tan P, Ma G, Nhung NT, Wang J, Zhou Y#. and Huang Y#. Optogenetic control of membrane tethering and interorganellar communication at nanoscales. Chemical Science. 2017 (DOI: 10.1039/c7sc01115f; # lead contact). *Highlighted as Cover Story; Featured in Vital Records and BioTechniques.

Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Zhou Y, Rao A, Sun D, You J, and Huang Y. Mutations in 5-methylcytosine oxidase TET2 and RHOA cooperatively disrupt T-cell homeostasis. Journal of Clinical Investigation. 2017,127(8):2990-3012 (PMID:28691982). *Featured in Vital Records.

Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J Wang RF and Cui J. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune response. Molecular Cell. 2016,64:1-15. (PMID: 27666593)

Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Par PK, Zhou J, Zhou Y, Hu ZZhou Y, Mark JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoixc HIF1α signaling in triple-negative breast cancer. Nature Cell Biology. 2016,18(2):213-24. (PMID: 26751287).

Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Zhang SL, Shi X, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, and Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a novel regulator of Ca2+ influx. Nature Cell Biology. 2015,17(10):1339-47. (PMID: 26322679). *Featured in NCB “News and Views”.

Ma G, Wei M, He L, Liu C, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wang J, Wang Y, and Zhou Y. Inside-out Ca2+ signaling prompted by STIM1 conformational switch. Nature Communications. 2015,6:7826. (PMID: 26184105) *Featured in eBioTrade as Highlighted News.

He L, Zhang Y, Ma G, Tan P, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Han G, and Zhou Y. Near Infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife. 2015,pii:e10024. (PMID: 26646180). *Highlighted in Biophotonics Magazine; Optics & Photonics News; ALN Magazine; The BattalionVital Records and Immuno-Oncology News.

Quintana A, Rajanikanth V, Farber-Katz S, Gudlur A, Zhang C, Jing J, Zhou Y, Rao A & Hogan PG. TMEM110 regulates the maintenance and remodeling of mammalian ER-Plasma membrane junctions competent for STIM-ORAI signaling. PNAS. 2015, 112(51):E7083-92. (PMID: 26644574).

Gudlur A*, Quintana A*, Zhou Y, Hirve N, Mahapatra S, Hogan PG. STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel. Nature Communications. 2014,5:5164 (PMID: 25296861).

Zhou Y, Srinivasan P, Razavi S, Seymour S, Meraner P, Stathopulos PB, Ikura M, Rao A, Hogan PG. Initial activation of STIM1, the regulator of store-operated calcium entry. Nature Structural & Molecular Biology. 2013,20(8):973-81. (PMID: 23851458). *Featured in NSMB “News and Views.

Zhou Y, Meraner P, Kwon, HT, Machnes D, Oh-hora Masatsugu, Zimmer Jochen, Huang Y, Stura A, Rao A and Hogan PG. STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nature Structural & Molecular Biology. 2010,17(1):112-116. (PMID: 20037597). *Highlighted on the cover of NSMB; “Featured Article” on Nature Signaling Gateway; Rated as “Must Read [F1000 article factor: 8]”.

Zhou Y, Ramachandran S, Oh-hora M, Rao A and Hogan PG. Pore architecture of the ORAI1 store-operated calcium channel. PNAS. 2010,107(11):4896-901. (PMID: 20194792)

Selected Reviews and Book Chapters (from a total of 40+ publications)

Rui Chen, Ji Jing, Siwko SK, and Zhou Y. Intelligent cell-based therapies for cancer and autoimmune disorders. Current Opinions in Biotechnology. 2020,66:207-16 (PMID: 32956902)

Nguyen NT, Guolin Ma, Zhou Y#, and Jing J#. Optogenetic approaches to control Ca2+-modulated physiological processes. Current Opinions in Physiology. 2020,17:187-96. (online)

Tan P, Han G, Huang Y and Zhou Y. Illuminating cell physiology with optogenetics. Physiological Reviews. 2020 (commissioned)

Haruehanroengra P, Zheng YY, Zhou Y, Huang Y and Sheng J. RNA modifications and cancer. RNA Biology. 2020:1-16. (PMID: 31994439)

Jing J, Liu G, Huang Y, and Zhou Y. A molecular toolbox for interrogation of membrane contact sites. Journal of Physiology. 2019 (PMID: 31119749)

Tan P, He L and Zhou Y. TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10. Autophagy. 2019,15(4):747-9. (PMID: 30653426)

Yu N, Huang L, Zhou Y#, Xue T#, Chen Z#, and Han G#. Near-infrared-light activatable nanoparticles for deep-tissue-penetrating wireless optogenetics. Advanced Healthcare Materials. 2019:31801132. (PMID: 30633858)

Mao J, Lin E, He L, Yu J, Tan P and Zhou Y. Autophagy and viral infection. Autophagy regulation of Innate Immunity. 2019,1209:55-78. (PMID: 31728865)

He L, Zhang Q, Zhou Y# and Hang Y#.Optogenetic approaches to control calcium entry in non-excitable cells. Calcium Entry Channels in Non-Excitable Cells. CRC Press, 2018. (PMID: 30299659)

Nguyen NT, Ma G, Lin E, O’Souza B, He L, Jing J, Huang Y and Zhou Y. CRAC channel-based optogenetics. Cell Calcium. 2018,75:79-88. (PMID: 30199756)

Tan P, He L, Han G, and Zhou Y. Optogenetic immunomodulation: shedding light on the immune system. Trends in Biotechnology. 2017,35(3):215-26. (PMID: 27692897)  

Ma G, Wen S, Huang Y, Wang Y and Zhou Y. Optogenetic toolkit for precise control of calcium signaling. Cell Calcium. 2017 (PMID: 28104276).

Ma G, Wen S, Huang Y and Zhou Y. The STIM-Orai pathway: Light-operated calcium entry through engineered CRAC channels. Store-operated Ca2+ entry (SOCE) pathways. 2017,993:117-38. (PMID: 28900912)

Zhang Y, Huang L, Li Z, Ma G, Zhou Y# and Han G#. Illuminating cell signaling with near-infrared light-responsive nanomaterials. ACS Nano. 2016,10(4):3881-5 (PMID: 27077481; #senior authors) 

Gudlur A, Zhou Y, and Hogan PG. STIM-ORAI interactions that control the CRAC channel. Current Topics in Membranes. 2013,71:33-58. (PMID: 23890110)

Full list available here.

Citations available here.